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Human NR5A2 + LRH1 Protein expressed in Wheat germ - ABIN1312989
Khan, Narayanan, Lu, Choo, Du, Wiradharma, Yang, Wan: Delivery of reprogramming factors into fibroblasts for generation of non-genetic induced pluripotent stem cells using a cationic bolaamphiphile as a non-viral vector. in Biomaterials 2013
Lrh-1 transcriptionally regulates Oat2.
Rev-erbalpha regulates Cyp7a1 and cholesterol metabolism through its repression of the Lrh-1 receptor.
transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas; findings support the notion that, in the pancreas, the transcriptional networks involved in differentiation-specific functions also suppress inflammatory programs; under conditions of genetic or environmental constraint, these networks can be subverted to foster inflammation
our data indicated that miR-381 inhibited migration and invasion of non-small cell lung cancer (NSCLC)by targeting LRH-1, and may represent a novel potential therapeutic target and prognostic marker for NSCLC.
NR5A2-mediated cancer cell survival is facilitated through augmentation of GATA6 and anti-apoptotic factor BCL-XL levels.
the expression level of LRH-1 can be used as a marker in the early diagnosis of unexplained recurrent spontaneous abortion.
Liver receptor homologue1 (LRH1) is a direct target of miR30d in colorectal carcinoma cells.
Results show that LRH-1 is a direct target gene of miR-374b and that decreased miR-374b expression may contribute to the promotion of LRH-1-mediated tumorigenesis of colon cancer.
NR5A2 may be important in the pathophysiology of preterm birth and exploring noncoding regulators of NR5A2 is warranted
Our study suggests that miR-219-5p regulated the proliferation, migration, and invasion of human gastric cancer cells by suppressing LRH-1.
Liver receptor homolog-1 was identified as a direct target gene of miR-136
miR-27b-3p levels were found to be significantly negatively correlated with both NR5A2 and CREB1 levels in breast cancer tissues.
The fusion transcript NR5A2-KLHL29FT was identified in normal and cancerous colonic epithelia. It is due to an uncharacterized polymorphic germline insertion of the NR5A2 sequence from chromosome 1 into the KLHL29 locus at chromosome 2, rather than a chromosomal rearrangement. NR5A2-KLH29FT expression levels were significantly lower in colon cancers than in matched normal colonic epithelia.
Additionally, the authors solved the structure of the human LRH-1 DNA-binding domain bound to a DR0 motif located within the Oct4 promoter.
miR-376c inhibits non-small-cell lung cancer cell growth and invasion by targeting LRH-1
The first crystal structure of the LRH-1-PGC1alpha complex , which depicts hydrophobic contacts is identified and described.
The dramatic repositioning is influenced by a differential ability to establish stable face-to-face pi-pi-stacking with the LRH-1 residue His-390, as well as by a novel polar interaction mediated by the RJW100 hydroxyl group. The differing binding modes result in distinct mechanisms of action for the two agonists.
The role of NR5A2 in regulating pancreatic cancer stem cell properties and epithelial-mesenchymal transition of pancreatic carcinoma cells
demonstrate aberrant expressions of SF-1 and LRH-1 in endometriotic granulosa-lutein cells
Down-regulation of MicroRNA-381 promotes cell proliferation and invasion in colon cancer cells through up-regulation of LRH-1.
GATA4 and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1, NR5A2, and the other steroidogenic markers.
NR5A2 (LRH-1, SF2) mRNA is upregulated in granulosa cells of dominant and hCG-induced ovulatory ovarian follicles.
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
nuclear receptor subfamily 5, group A, member 2
, Ftz-F1-related orphan receptor A
, FTZ-F1-related nuclear orphan receptor
, Ftz-F1-related orphan receptor
, liver receptor-like protein 1
, CYP7A promoter-binding factor
, alpha-1-fetoprotein transcription factor
, b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus
, fetoprotein-alpha 1 (AFP) transcription factor
, hepatocytic transcription factor
, liver nuclear receptor homolog-1 variant 2
, liver receptor homolog 1
, liver receptor homolog-1
, nuclear receptor NR5A2
, nuclear receptor subfamily 5 group A member 2
, Ftz-F1-related orphan receptor B
, fetoprotein transcription factor
, FTZ-F1 beta
, FTZ-F1 beta2 protein