anti-Human NR0B2 Antikörper für Enzyme Immunoassay

Recommended NR0B2 Antibody

Antigen
Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2) Antikörper
  • SHP
  • SHP1
  • SHP-1
  • Shp1
  • Shp
  • NR0B2-A
  • Nr0b2
  • SHP-A
  • gb:bc058069
  • nuclear receptor subfamily 0 group B member 2
  • nuclear receptor subfamily 0, group B, member 2
  • nuclear receptor subfamily 0, group B, member 2a
  • NR0B2
  • Nr0b2
  • nr0b2a
Epitop
AA 56-83, Middle Region
18
11
10
7
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human
89
20
19
6
6
6
3
3
2
2
1
1
Wirt
Kaninchen
71
16
4
Klonalität
Polyklonal
Konjugat
Dieser NR0B2 Antikörper ist unkonjugiert
4
3
3
2
2
2
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
73
39
32
27
17
13
13
6
3
1
1
1
Optionen

Bilder

Produktnummer ABIN953745
$ 484.00
Zzgl. Versandkosten $45.00

General

Antigen Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2) Antikörper
Epitop AA 56-83, Middle Region
(18), (11), (10), (7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(89), (20), (19), (6), (6), (6), (3), (3), (2), (2), (1), (1)
Wirt Kaninchen
(71), (16), (4)
Klonalität
Polyklonal
Konjugat Dieser NR0B2 Antikörper ist unkonjugiert
(4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(73), (39), (32), (27), (17), (13), (13), (6), (3), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller

Produktdetails anti-NR0B2 Antikörper

Target Details NR0B2 Anwendungsinformationen Handhabung Referenzen für anti-NR0B2 Antikörper (ABIN953745) Bilder
Spezifität This antibody reacts to NR0B2.
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Affinity chromatography on Protein A
Immunogen KLH conjugated synthetic peptide between 56-83 amino acids from the Central region of human NR0B2
Isotyp Ig Fraction
Plasmids, Primers & others

Target Details NR0B2

Produktdetails anti-NR0B2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-NR0B2 Antikörper (ABIN953745) Bilder zurück nach oben
Antigen
Andere Bezeichnung NR0B2 (NR0B2 Antibody Abstract)
Hintergrund The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.Synonyms: Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, SHP, Small heterodimer partner
Molekulargewicht 28058 Da
Gen-ID 8431
NCBI Accession NP_068804
Pathways Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway

Anwendungsinformationen

Produktdetails anti-NR0B2 Antikörper Target Details NR0B2 Handhabung Referenzen für anti-NR0B2 Antikörper (ABIN953745) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-NR0B2 Antikörper Target Details NR0B2 Anwendungsinformationen Referenzen für anti-NR0B2 Antikörper (ABIN953745) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-NR0B2 Antikörper (ABIN953745)

Produktdetails anti-NR0B2 Antikörper Target Details NR0B2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Zhou, Zhang, Macchiarulo, Yang, Cellanetti, Coto, Xu, Pellicciari, Wang: "Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes." in: The Journal of biological chemistry, Vol. 285, Issue 32, pp. 24871-81, 2010

Kim, Kim, Cho, Kim, Kim, Cheong: "SHP (small heterodimer partner) suppresses the transcriptional activity and nuclear localization of Hedgehog signalling protein Gli1." in: The Biochemical journal, Vol. 427, Issue 3, pp. 413-22, 2010

Yang, Wu, Zheng, Lu, Ma, Jia, Hu: "Gender-dependent penetrance of small heterodimer partner (SHP) gene deficiency in overweight/obese Chinese pedigrees." in: The Journal of international medical research, Vol. 38, Issue 1, pp. 142-9, 2010

Roberts, Kawut, Krowka, Brown, Trotter, Shah, Peter, Tighiouart, Mitra, Handorf, Knowles, Zacks, Fallon,: "Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease." in: Gastroenterology, Vol. 139, Issue 1, pp. 130-9.e24, 2010

Ondracek, Rushing, Reese, Oropeza, McLachlan: "Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis." in: Journal of virology, Vol. 83, Issue 23, pp. 12535-44, 2009

Bilder

Produktdetails anti-NR0B2 Antikörper Target Details NR0B2 Anwendungsinformationen Handhabung Referenzen für anti-NR0B2 Antikörper (ABIN953745) zurück nach oben
Bilder des Herstellers
Immunofluorescence (IF) image for anti-Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2) (AA 56-83), (Middle Region) antibody (ABIN953745) Confocal immunofluorescent analysis of NR0B2 Antibody (Center)(Cat#AP52928PU-N) with ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2) (AA 56-83), (Middle Region) antibody (ABIN953745) NR0B2 antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin ...
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2) (AA 56-83), (Middle Region) antibody (ABIN953745) NR0B2 Antibody (Center)(PEI 1/100) western blot analysis in HepG2 cell line lysates (...