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The proximity of the expression of dax1 to 5th branchial arch and numerous known tooth markers led us to hypothesize that dax1 is involved in pharyngeal tooth development in the zebrafish.
Based on the level of NR0B1 expression in lung adenocarcinoma cells with different clinical stages, our results indicate that epigenetic modifications promote NR0B1 activation to maintain the self-renewal of cancer cells.
Nonsense mutation in the DAX-1 gene is associated with precocious puberty and late-onset hypogonadotropic hypogonadism.
These findings suggested that the mutation of NR0B1 in X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism enhanced the function of DAX1 to repress SF-1 (zeige NR5A1 Proteine) activation, while DAX1 is expected to have additional roles in the pathological mechanism.
DAX1 and SF1 (zeige NR5A1 Proteine) expression positively correlated in pediatric adrenocortical tumors, suggesting that these transcription factors might cooperate in adrenocortical tumorigenesis.
This novel mutation (p. V385L) of DAX-1 is the first to be identified in association with secretory azoospermia, thereby highlighting the important role of DAX-1 in spermatogenesis.
DAX-1 is less specific than Ap2beta (zeige AP2B1 Proteine), however it is a sensitive marker for translocation positive ARMS and can be helpful in their diagnosis if used in combination with Ap2beta (zeige AP2B1 Proteine)
DAX1 mutations were associated with X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.
Case Report: novel mutation in the NR0B1 (DAX1) gene in a large family with two boys affected by congenital adrenal hypoplasia.
DAX-1 protein is necessary to maintain normal spermatogenesis. In humans, male fertility has been studied in few patients carrying DAX-1 mutations. Review.
results suggest a previously unknown DAX-1/beta-Catenin (zeige CTNNB1 Proteine) molecular network controlling HCC (zeige FAM126A Proteine) development
CpG methylation within the NR0B1 promoter is not involved in the in vivo regulation of NR0B1 expression, whereas the hyperacetylation of histone H4 and the unmethylation of histones H3K9 and H3K27, and their binding to the NR0B1 promoter results in decondensed euchromatin for NR0B1 activation.
Sf1 (zeige SF1 Proteine) SUMOylation and Dax1 have roles in the physiological cessation of FAdE-mediated Sf1 (zeige SF1 Proteine) expression and the resultant regression of the postnatal fetal cortex (X-zone)
Findings indicate that the Gata6 (zeige GATA6 Proteine) promoter is activated by Esrrb in association with Ncoa3 (zeige NCOA3 Proteine), and Dax1 inhibited activities of Esrrb and Ncoa3 (zeige NCOA3 Proteine), resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.
Data indicate that nuclear receptor subfamily 0 group B member 1 (Nr0b1) interacted with androgen receptor (AR (zeige AR Proteine)) in Sertoli cells (SCs (zeige TWIST1 Proteine)).
Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells
Dax1 and Nanog have roles in stabilizing mouse embryonic stem cells and induced pluripotency
Here we review the current knowledge on properties, functions and mechanisms of DAX1 action.
Insulin (zeige INS Proteine)-mediated induction of DAX-1 in Leydig cells of testis may be a key regulatory step of serum sex hormone level in insulin (zeige INS Proteine)-resistant states.
Dax1 functions as a negative regulator of Esrrb and Oct3/4 (zeige POU5F1 Proteine), and these molecules form a regulatory loop for controlling the pluripotency and self-renewal capacity of embryonic stem cells.
Transcriptional differences between mouse embryonic and epiblast stem cells is mediated through a Sox2 (zeige SOX2 Proteine)/Esrrb heterodimer regulating Nr0b1.
Involvement of Ad4BP/SF-1 (zeige NR5A1 Proteine), DAX-1, and COUP-TFII (zeige NR2F2 Proteine) transcription factor on steroid production and luteinization in ovarian theca cells.
the decrease of Dax-1 transcription factor and the increase in histone H3 (zeige HIST3H3 Proteine) acetylation may play important roles in progesterone synthesis in luteinizing granulosa cells.
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
, nuclear receptor subfamily 0 group B member 1
, nuclear receptor subfamily 0, group B, member 1
, orphan nuclear receptor DAX-1
, DSS-AHC critical region on the X chromosome, gene 1
, DSS-AHC critical region on the X chromosome protein 1
, nuclear hormone receptor
, nuclear receptor DAX-1
, nuclear receptor DAX1
, adrenal hyoplasia protein DAX1
, adrenal hypoplasia congenital
, adrenal hypoplasia congenita-like protein
, adrenal hypoplasia, congenital homolog