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Human PRKACA Protein expressed in Wheat germ - ABIN1316219
Loilome, Yooyuen, Namwat, Sithithaworn, Puapairoj, Kano, Noguchi, Miwa, Yongvanit: PRKAR1A overexpression is associated with increased ECPKA autoantibody in liver fluke-associated cholangiocarcinoma: application for assessment of the risk group. in Tumour biology 2012
Ezrin (zeige EZR Proteine)-anchored PKA phosphorylates serine 369 and 373 on connexin 43 (zeige GJA1 Proteine) to enhance gap junction assembly, communication, and cell fusion.
CaV1.4 (zeige CACNA1F Proteine) channels are indeed modulated by PKA phosphorylation within the inhibitor of Ca(2 (zeige CA2 Proteine)+)-dependent inactivation (ICDI) motif.
In this study, the authors linked for the first time the loss of RIIbeta (zeige PRKAR2B Proteine) protein levels to the PRKACA mutation status and found the down-regulation of RIIbeta (zeige PRKAR2B Proteine) to arise post-transcriptionally.
the presence of lipofuscin in cortisol-producing adenomas (CPAs) responsible for Cushing syndrome with and without the PRKACA (pLeu206Arg) somatic mutation, was investigated.
Mechanistically, Sirt1 (zeige SIRT1 Proteine) expression elevates phosphorylation of the alpha subunit (zeige POLG Proteine) of protein kinase A (PKA alpha), and this event is essential for Sirt1 (zeige SIRT1 Proteine)-induced phosphorylation of beta Catenin (zeige CTNNB1 Proteine).
Together, the results suggest a complex antagonistic interplay between the control of ARPP-16 (zeige ARPP19 Proteine) by MAST3 and PKA that creates a mechanism whereby cAMP mediates PP2A (zeige PPP2R4 Proteine) disinhibition.
CTR (zeige CALCR Proteine) activates AKAP2-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 (zeige TJP1 Proteine) and claudin 3 (zeige CLDN3 Proteine).
These results indicate that Mixed fibrolamellar hepatocellular carcinoma (mFL-HCC (zeige FAM126A Proteine)) is similar to pure FL-HCC (zeige FAM126A Proteine) at the genomic level and the DNAJB1 (zeige DNAJB1 Proteine):PRKACA fusion can be used as a diagnostic tool for both pure and mFL-HCC (zeige FAM126A Proteine)
PRKACA mutations are highly specific for cortisol over-secretion, while they are absent or very rare in the context of other adrenal diseases. Patients carrying these somatic mutations are affected by a more severe phenotype and are identified at a younger age.
Somatic mutations in PRKACA, coding for the catalytic alpha subunit (zeige POLG Proteine) of protein kinase A (PKA), have been recently identified as the most frequent genetic alteration in cortisol-secreting adrenocortical adenomas, which are responsible for adrenal Cushing's syndrome.
PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
Data indicate that mitochondrial cAMP-dependent protein kinase (PKA) activity is regulated by the protease calpain.
structural basis of selectivity for protein kinase A in complex with Rho-kinase (zeige ROCK1 Proteine) inhibitors by x-ray crystallography
Purification and characterisation of protein kinase catalytic subunit (PKAcat) from bovine lens.
ceramide as a potent physiological modulator of the Na(+)-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta (zeige PRKCZ Proteine)
we demonstrate that PKA, PKC (zeige FYN Proteine) and PI3K pathways crosstalk in porcine male germ cells to crucially regulate GSK3A (zeige GSK3a Proteine) phosphorylation which subsequently controls cell motility.
Study validates the DNAJB1 (zeige DNAJB1 Proteine)-PRKACA fusion kinase as an oncogenic driver and candidate drug target for fibrolamellar hepatocellular carcinoma in mouse model in which tumorigenesis was significantly enhanced by genetic activation of beta-catenin (zeige CTNNB1 Proteine).
Protein kinase A signaling explains vasopressin (zeige AVP Proteine)-mediated regulation of membrane trafficking and gene transcription.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB (zeige CREB1 Proteine) signaling.
HIF1a (zeige HIF1A Proteine) transcriptional activity is stimulated by Protein kinase A-dependent phosphorylation
Generation of the Dnajb1 (zeige DNAJB1 Proteine)-Prkaca fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human fibrolamellar hepatocellular carcinonma.
Data indicate a subpopulation of the CaV1.2 (zeige CACNA1C Proteine) channel pore-forming subunit (alpha1C) within nanometer proximity of protein kinase A (PKA) at the sarcolemma of murine and human arterial myocytes.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (zeige SCP2 Proteine)), a form of synaptic plasticity that requires Cav1.2 (zeige CACNA1C Proteine) and enhancement of its activity by the beta2-adrenergic receptor (zeige ADRB2 Proteine) (beta2AR (zeige ADRB2 Proteine))-cAMP-PKA cascade.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (zeige NRG1 Proteine) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
study identifies a new role of Dual-AKAP1 (zeige AKAP1 Proteine) in regulating mitochondrial trafficking through Miro-2 (zeige RHOT2 Proteine), and supports a model in which PINK1 (zeige PINK1 Proteine) and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity
Data suggest that enzyme activation by cAMP involves highly stable conformation of Prkar1a as it binds to Prkaca; glycine residue, G235, appears to function as hinge in B/C helix conserved in Prkar1a; this "Flipback" conformation plays role in cAMP association to A domain of Prkar1a. (Prkar1a = cyclic AMP-dependent protein kinase RIalpha subunit; Prkaca = cyclic AMP-dependent protein kinase catalytic subunit)
support hypothesis that PRKACA activation is responsible for downstream protein tyrosine phosphorylation events in stallion sperm
Thus Ca(2 (zeige CA2 Proteine)+)-cAMP/PKA-dependent phosphorylation limits the rate and magnitude of increase in spontaneous action potential firing rate.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
, cAMP-dependent protein kinase catalytic subunit alpha
, protein kinase A catalytic subunit
, cAMP-dependent protein kinase catalytic subunit C alpha
, protein kinase A
, protein kinase, cAMP-dependent, catalytic, alpha
, C-alpha subunit
, sperm cAMP-dependent protein kinase catalytic subunit
, protein kinase A alpha
, PKA catalytic subunit alpha