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The basic residues Lys (zeige LYZ Proteine)-717 and Lys (zeige LYZ Proteine)-719 in the C-terminal region of ANK7 contribute to IkappaBzeta (zeige NFKBIZ Proteine) binding to the Lcn2 (zeige LCN2 Proteine) promoter, probably via interaction with the cytosine-rich element required for Lcn2 (zeige LCN2 Proteine) activation; glutamate (zeige GRIN1 Proteine) substitution for both lysines results in a loss of transcriptionally active complex formation without affecting direct contact of IkappaBzeta (zeige NFKBIZ Proteine) with p50 (zeige LSP1 Proteine).
The data imply that regulation of these c-Rel (zeige NFkBP65 Proteine)-dependent lymphoid responses is a non-redundant function of IkappaBepsilon.
temporal control of NF-kappaB (zeige NFKB1 Proteine) activation by the coordinated degradation and synthesis of IkappaB proteins
IkappaBepsilon deficiency in mice leads to neonatal death, elevated kappaB binding activity, overexpression of NF-kappaB (zeige NFKB1 Proteine) target genes, and disruption of lymphocyte production.
Neither IkappaBalpha (zeige NFKBIA Proteine) nor IkappaBepsilon deficiency had major effects on natural killer cell generation while their combined absence led to NF-kappaB (zeige NFKB1 Proteine) hyperactivation.
An important role is proposed for I kappa B epsilon in the differential regulation of nuclear NF-kappa B (zeige NFKB1 Proteine) activity in stimulated B cells.
In vivo degradation rate constants were measured for NF-kappaB (zeige NFKB1 Proteine)-bound & -unbound IkappaB. Models suggest differential degradation rates of free & bound IkappaB may be a new cross-regulation mechanism imparting functional robustness to the signaling module.
identify NFKBIE aberrations as a common genetic event across B-cell malignancies and highlight NFKBIE deletions as a novel poor-prognostic marker in PMBL.
We suggest that the impairment of NFKBIE gene function can reduce the uptake of methotrexate into cells, suggesting that the gene is an important factor for rheumatoid arthritis outcome
A NFKBIE polymorphism was associated with increased risk of pneumococcal meningitis.
results show that Gal-1 (zeige LGALS1 Proteine) acts by inhibiting the stimulation of the LPS (zeige IRF6 Proteine)-induced IkappaBzeta (zeige NFKBIZ Proteine) expression, an NF-kappaB (zeige NFKB1 Proteine) regulator involved in IL-6 (zeige IL6 Proteine) gene transcription.
Newly identified alterations included recurrent promoter mutations of NFKBIE, encoding NF-kappaB (zeige NFKB1 Proteine) inhibitor varepsilon (IkappaBvarepsilon), in 14.5% of samples of desmoplastic melanoma
IkappaBepsilon has a role in NF-kappaB (zeige NFKB1 Proteine) regulation in aggressive chronic lymphocytic leukemia
Vitamin C forestalls cigarette smoke induced NF-kappaB (zeige NFKB1 Proteine) activation in alveolar epithelial cells.
we identified two gene loci associated with rheumatoid arthritis susceptibility- NFKBIE and RTKN2 (zeige RTKN2 Proteine)
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon
An NFKBIE SNP associated with susceptibility to pneumococcal disease but not pneumococcal empyema.
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus.
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
, NF-kappa-B inhibitor epsilon
, solute carrier family 35, member B2