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ABR depletion leads to G2/M accumulation in human embryonic stem cells. Centrosome dynamics and mitotic fidelity are compromised upon ABR depletion. When mitosis progresses without ABR, human embryonic stem cells show a high incidence of aneuploidy.
During vestibular morphogenesis, Abr and Bcr play complementary roles. Small Rho-related GTPases like Abr and Bcr are important for balance and motor coordination.
Loss of abr expression causes defects in spine development.
These results identify Abr-regulated CD4(+) T cell migration as an important component of severe cockroach allergen-evoked allergic asthma in mice.
Bcr and Abr play a critical role in down-regulating hypoxia-induced pulmonary hypertension by deactivating Rac1.
Abr and Bcr play important complementary roles during vestibular morphogenesis
These results identify Abr and Bcr as the only GTPase-activating proteins to date that specifically negatively regulate Rac function in vivo in primary macrophages.
These data show that Abr and Bcr normally curb very specific functions of mature tissue innate immune cells.
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene.
active breakpoint cluster region-related protein