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Mammalian Monoclonal FGF12 Primary Antibody für ISt, IHC - ABIN1304629
Wildburger, Ali, Hsu, Shavkunov, Nenov, Lichti, LeDuc, Mostovenko, Panova-Elektronova, Emmett, Nilsson, Laezza: Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain. in Molecular & cellular proteomics : MCP 2015
Human Monoclonal FGF12 Primary Antibody für IHC (p), ELISA - ABIN560869
Chattopadhyay, Singh, Phukan, Purkayastha, Kataki, Mahanta, Saxena, Kapur: Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India. in Mutation research 2010
In this study, the authors observed that rs1460922 of FGF12 was significantly associated with VT and identified that a de novo variation of FGF12 may be an important genetic risk factor for the pathogenesis of VT.
FGF12, RBFOX1 (zeige A2BP1 Antikörper), and MIR302F could be important in human heterotaxy, because they were noted in multiple cases. Further investigation into genes involved in the NODAL, BMP, and WNT (zeige WNT2 Antikörper) body patterning pathways and into the dosage effects of FGF12, RBFOX1 (zeige A2BP1 Antikörper), and MIR302F is warranted.
FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation.
Results demonstrate that gain-of-function FHF mutations can cause neurologic disorder, and expand the repertoire of genetic causes (FHF1) and mechanisms (altered Nav gating) underlying early-onset epileptic encephalopathies and cerebellar atrophy
Nine SNPs of the FGF12 gene were associated with Kashin-Beck disease.
Data indicate that SCN5A (zeige SCN5A Antikörper) variant (Nav1.5 (zeige SCN5A Antikörper)) p.H1849R affected interaction with fibroblast growth factor homologous factor (FHFs).
Q7R-FGF12 is a disease-associated BrS mutation. Moreover, these data suggest for the first time that FHF effects on Na(+) and Ca(2 (zeige CA2 Antikörper)+) channels are separable.
VAX1 (zeige VAX1 Antikörper) rs10787760, rs6585429 and rs1871345 polymorphisms may be involved in nonsyndromic cleft lip with or without cleft palate in Brazilian patients, but there is no association with polymorphisms in FGF12, VCL (zeige VCL Antikörper), or CX43 (zeige GJA1 Antikörper)
PHOX2B (zeige PHOX2B Antikörper), FGF12 and GAD2 (zeige GAD2 Antikörper) genes are hypermethylated in colorectal neoplastic tissue
exogenous FGF12 can play a role in tissues by translocating into cells through the plasma membrane
FGF21 (zeige FGF21 Antikörper) does not appear necessary for exercise-induced systemic and hepatic mitochondrial adaptations, but the increased adiposity, hyperinsulinemia, and impairments in hepatic mitochondrial function induced by FGF21 (zeige FGF21 Antikörper) deficiency can be partially rescued by daily wheel running exercise.
x-ray crystal structure of FHF1b
results argue strongly against the possibility that FHF1 has a modulatory effect on the Na(v)1.9 sodium channel isoform in cRet (zeige RET Antikörper)+/IB4+ neurons, but FHF1 could play a role in a distinct subset of TrkA (zeige NTRK1 Antikörper)+/CGRP (zeige CALCA Antikörper)+ nociceptors.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
fibroblast growth factor 12
, Fibroblast growth factor 12
, fibroblast growth factor 12B
, fibroblast growth factor FGF-12b
, fibroblast growth factor homologous factor 1
, myocyte-activating factor
, fibroblast growth factor homologous factor 1b