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Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble (zeige SCRIB Proteine) PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC (zeige MCC Proteine) were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2 (zeige RPS6KA3 Proteine); MCC (zeige MCC Proteine) = mutated in colorectal cancer protein)
RSK1 (zeige RPS6KA1 Proteine) and 3 but not RSK2 (zeige RPS6KA3 Proteine) are down-regulated in breast tumour and are associated with disease progression. RSK (zeige RPS6KA1 Proteine) may be a key component in the progression and metastasis of breast cancer.
Data indicate that S6 kinase 2 (S6K2 (zeige RPS6KB2 Proteine)) can phosphorylate histone H3 (zeige HIST3H3 Proteine) at position Thr45, which may play a role during cell proliferation and/or differentiation.
Kinome screening revealed RPS6KA2 expression, in human pancreatic cancer cells, protects against erlotinib induced apoptosis.
genetic association study in Han population in China: Data suggest that SNPs in RSK3 (rs2229712) and in MEK1 (zeige MAP2K1 Proteine) (rs28730804) demonstrate gene-gene interaction that affects antidepressant drug outcome in female patients with major depressive disorder.
Overexpression of RSK3 or RSK4 (zeige RPS6KA6 Proteine) supports tumor cell proliferation upon PI3K (zeige PIK3CA Proteine) inhibition both in vitro and in vivo therby contributing to drug resistance.
p90RSK2 is dispensable for BCR-ABL (zeige ABL1 Proteine)-induced myeloid leukemia (zeige BCL11A Proteine), but may be required for pathogenesis and lineage determination in FLT3 (zeige FLT3 Proteine)-internal tandem duplication-induced hematopoietic transformation.
Data show that genetic variation in RPS6KA1 (zeige RPS6KA1 Proteine), RPS6KA2, and PRS6KB2 were associated with risk of developing colon cancer while only genetic variation in RPS6KA2 was associated with altering risk of rectal cancer.
Characterization of the terminal domain as a protein kinase
chronic activation CREB (zeige CREB1 Proteine) and p90RSK (zeige RPS6KA1 Proteine) in the epileptic hippocampus may be closely associated with the histopathological changes of Ammon's horn sclerosis
We confirmed that Raf1 (zeige RAF1 Proteine)(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 was increased in Raf1 (zeige RAF1 Proteine)(L613V) mice. Constitutive RSK3 gene deletion prevented the Raf1 (zeige RAF1 Proteine)(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
RSK3 is required for the induction of interstitial cardiac fibrosis in alpha-tropomyosin (zeige TPM1 Proteine) Glu180Gly transgenic mice.
Anchored RSK3 transduces signals that modulate pathologic myocyte growth in cardiac hypertrophy.
p90RSK2 is dispensable for BCR-Abl (zeige ABL1 Proteine)-induced myeloid leukemia (zeige BCL11A Proteine), but may be required for pathogenesis and lineage determination in Flt3 (zeige FLT3 Proteine)-internal tandem duplication-induced hematopoietic transformation.
activation and translocation of p90 (zeige GPAM Proteine) ribosomal S6 protein kinase (zeige CDK7 Proteine) requires RANTES (zeige CCL5 Proteine)-mediated chemokine (zeige CCL1 Proteine) transcription in astrocytes
p90Rsk2 and Emi1 functionally interact during oocyte maturation
inhibition of p90RSK (zeige RPS6KA1 Proteine) prevented H2O2-mediated cTnI (zeige TNNC1 Proteine) (Ser (zeige SIGLEC1 Proteine)(23/24)) phosphorylation but not ERK1/2 and PKCalpha (zeige PKCa Proteine)/betaII activation
p90RSK (zeige RPS6KA1 Proteine) is a novel regulator of cardiac NHE1 (zeige SLC9A1 Proteine) activity by phosphorylating NHE1 (zeige SLC9A1 Proteine) serine 703 and a new pathological mediator of I/R injury in the heart
there is a functional link between S6K1 (zeige RPS6KB1 Proteine) II and CK2 (zeige CSNK2A1 Proteine) signaling, which involves the regulation of S6K1 (zeige RPS6KB1 Proteine) II nuclear export by CK2 (zeige CSNK2A1 Proteine)-mediated phosphorylation of Ser (zeige SIGLEC1 Proteine)-17
RSK2 (zeige RPS6KA3 Proteine) is a key regulator for cell transformation induced by tumor promoters such as EGF (zeige EGF Proteine) and TPA (zeige PLAT Proteine).
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ribosomal protein S6 kinase alpha-2
, ribosomal protein S6 kinase, 90kD, polypeptide 2
, 90 kDa ribosomal protein S6 kinase 2
, MAP kinase-activated protein kinase 1c
, MAPK-activated protein kinase 1c
, MAPKAP kinase 1c
, p90-RSK 2
, ribosomal S6 kinase 3
, ribosomal protein S6 kinase alpha 2
, S6K-alpha 2
, protein-tyrosine kinase Mpk-9