anti-Maus ERK2 Antikörper für Flow Cytometry

Recommended ERK2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Mitogen-Activated Protein Kinase 1 (MAPK1) Antikörper
  • ERK
  • ERK2
  • ERT1
  • MAPK2
  • P42MAPK
  • PRKM1
  • PRKM2
  • p38
  • p40
  • p41
  • p41mapk
  • 9030612K14Rik
  • AA407128
  • AU018647
  • C78273
  • Erk2
  • Prkm1
  • p42mapk
  • zERK2
  • MAPK1
  • Xp42
  • erk
  • erk2
  • ert1
  • mapk
  • mapk1b
  • mapk2
  • mpk1
  • prkm1
  • prkm2
  • mapk1
  • mapk1a
  • xp42
  • ATMPK1
  • F14N23.9
  • F14N23_9
  • MITOGEN-ACTIVATED PROTEIN KINASE
  • mitogen-activated protein kinase 1
  • mitogen-activated protein kinase 1
  • mitogen activated protein kinase 1
  • mitogen-activated protein kinase 1 L homeolog
  • mitogen-activated protein kinase 1 S homeolog
  • MAPK1
  • Mapk1
  • mapk1
  • mapk1.L
  • mapk1.S
  • PfMAP1
  • MPK1
  • PVX_084965
  • LOC9328617
  • Tsp_01601
Reaktivität
Human, Maus
352
149
119
51
31
19
14
11
10
9
9
7
5
5
2
2
2
2
2
1
1
Wirt
Maus
168
168
16
8
3
Klonalität
Monoklonal
Konjugat
Dieser ERK2 Antikörper ist unkonjugiert
10
9
8
7
7
4
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
1
Applikation
ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
329
160
95
83
82
61
53
27
22
10
5
3
3
2
2
1
1
1
1
1
1
1
1
Optionen
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Produktnummer ABIN2869484
$ 464.29
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN4903606 FACS IF IHC WB Mouse IgG Anmelden zum Anzeigen 0
1 ABIN2470904 FACS IHC ELISA WB Mouse IgG2b Anmelden zum Anzeigen 3F8 0
1 ABIN1838595 FACS ELISA WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN221449 ICC FACS IF IP ELISA WB Rabbit IgG pThr180, pTyr182 Anmelden zum Anzeigen 0
1 ABIN220478 FACS IP WB Mouse IgG1 pThr180, pTyr182 Anmelden zum Anzeigen 0
1 ABIN5682716 ELISA FACS IHC (p) WB Mouse IgG2b Anmelden zum Anzeigen 3F8 0
1 ABIN220470 FACS IHC (p) ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2666104 FACS Rabbit IgG Anmelden zum Anzeigen Polyclonal 1

General

Antigen Mitogen-Activated Protein Kinase 1 (MAPK1) Antikörper
Reaktivität Human, Maus
(352), (149), (119), (51), (31), (19), (14), (11), (10), (9), (9), (7), (5), (5), (2), (2), (2), (2), (2), (1), (1)
Wirt Maus
(168), (168), (16), (8), (3)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser ERK2 Antikörper ist unkonjugiert
(10), (9), (8), (7), (7), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1)
Applikation ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
(329), (160), (95), (83), (82), (61), (53), (27), (22), (10), (5), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-ERK2 Antikörper

Target Details ERK2 Anwendungsinformationen Handhabung Referenzen für anti-ERK2 Antikörper (ABIN2869484) Bilder
Verwendungszweck Purified Mouse Monoclonal Antibody
Produktmerkmale Synonyms: Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, 2.7.11.24, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, MAPK1, ERK2, PRKM1, PRKM2
Immunogen Purified recombinant fragment of human MAPK expressed in E. Coli.

Antigen Type: Recombinant Protein
Klon 3F8
Isotyp IgG2b

Target Details ERK2

Produktdetails anti-ERK2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-ERK2 Antikörper (ABIN2869484) Bilder zurück nach oben
Antigen
Andere Bezeichnung MAPK1 (MAPK1 Antibody Abstract)
Hintergrund Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors such as U0126 and PD98059.
Molekulargewicht 41390 Da
Gen-ID 5594
NCBI Accession NP_620407
UniProt P28482
Pathways MAPK Signalweg, RTK Signalweg, Apoptose, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process, Autophagie, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals

Anwendungsinformationen

Produktdetails anti-ERK2 Antikörper Target Details ERK2 Handhabung Referenzen für anti-ERK2 Antikörper (ABIN2869484) Bilder zurück nach oben
Applikationshinweise The suggested dilution is: Western Bloting: = 1:500 - 2000. Flow cytometry: = 1:200 - 400.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-ERK2 Antikörper Target Details ERK2 Anwendungsinformationen Referenzen für anti-ERK2 Antikörper (ABIN2869484) Bilder zurück nach oben
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months

Referenzen für anti-ERK2 Antikörper (ABIN2869484)

Produktdetails anti-ERK2 Antikörper Target Details ERK2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Lønne, Masoumi, Lennartsson, Larsson: "Protein kinase Cdelta supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33456-65, 2009

Tabakoff, Saba, Printz, Flodman, Hodgkinson, Goldman, Koob, Richardson, Kechris, Bell, Hübner, Heinig, Pravenec, Mangion, Legault, Dongier, Conigrave, Whitfield, Saunders, Grant, Hoffman,: "Genetical genomic determinants of alcohol consumption in rats and humans." in: BMC biology, Vol. 7, pp. 70, 2009

Schiemann, Graves, Baumann, Morella, Gearing, Nielsen, Krebs, Nathanson: "Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 12, pp. 5361-5, 1995

Gonzalez, Raden, Rigby, Davis: "Heterogeneous expression of four MAP kinase isoforms in human tissues." in: FEBS letters, Vol. 304, Issue 2-3, pp. 170-8, 1992