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we have shown that miR (zeige MLXIP Proteine)-1275 is a novel negative regulator of human visceral preadipocyte differentiation, which appears to act via post-transcriptional silencing of ELK1.
Purified ELK1 and AR bound with a dissociation constant of 1.9 x 10(-8) m A purified mutant ELK1 in which the D-box and DEF motifs were disrupted did not bind AR.
Study identified ELK1 as a novel target for miR (zeige MLXIP Proteine)- 150 which is up-regulated in apoptotic human umbilical cord vein endothelial cells.
Study identified a core region encompassing nt - 118 to + 108 of IPO4 gene that is necessary for its promoter activity. Transcription factors binding to this region were screened, resulting in the identification of two members of the Ets family, Ets-like transcription factor-1 and GA binding protein, which repress or activate its promoter activity, respectively.
High expression of ELK1 is associated with cholangiocarcinoma.
Overexpression of PAD4 (zeige PADI4 Proteine) constrains the activity of EMT (zeige ITK Proteine) via suppressing Elk1 expression.
These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease.
Downregulated expression of transcriptional activator ELK-1 may play an important role in the pathogenesis of atrial fibrillation.
ELK1 is likely to be activated in prostate cancer cells and promote tumor progression. Furthermore, silodosin that inactivates ELK1 in prostate cancer cells not only inhibits their growth but also enhances the cytotoxic activity of gemcitabine.
results suggest that ELK1 plays an important role in bladder tumorigenesis and cancer progression.
the effects of vitamin C inhibiting the apo(a) expression were attenuated by ELK1siRNA and Tet2siRNA. These results suggested vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells
A role for Elk-1 in the transcriptional regulation of DUSP5 (zeige DUSP5 Proteine)
TNF-alpha (zeige TNF Proteine) modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1.
novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK (zeige MAPK14 Proteine))/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH.
Data show that formation of a Krupple-like factor KLF4 (zeige KLF4 Proteine), pELK-1, and histone de-acetylase 2 (HDAC2 (zeige HDAC2 Proteine)) multiprotein complex dependent on the SM22alpha (zeige TAGLN Proteine) G/C Repressor element.
increased protein levels, phosphorylation and nuclear localization of Elk-1 observed in exon-1 and full-length Huntington's disease models could be a compensatory mechanism activated by striatal cells that contributes to neuroprotection
Fibroblast growth factor 21 (zeige FGF21 Proteine) induces glucose transporter-1 (zeige SLC2A1 Proteine) expression through activation of the serum response factor/Ets (zeige ETS1 Proteine)-like protein-1 in adipocytes
Elk-1 phosphorylation downstream from extracellular signal-regulated kinase is a key molecular event involved in long-term neuronal and behavioral adaptations to cocaine.
we aimed to identify the critical promoter regions of SPG4 (zeige SPAST Proteine) gene and effects of Elk1 on SPG4 (zeige SPAST Proteine) gene expression
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.
ETS domain-containing protein Elk-1
, ETS-like gene 1
, tyrosine kinase (ELK1) oncogene
, ELK1, member of ETS oncogene family S homeolog
, ternary complex factor Elk-1