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Downregulation of the expression of DUSP1 or protein phosphatase 1 led to a decline in the beta2adrenergic receptormediated dephosphorylation of ERK1/2
human plasma protects against endothelial cell apoptosis through sustained BAD phosphorylation, which is achieved by, at least in part, a novel interaction between PP1 (zeige PPA1 Proteine) with PAI1 (zeige SERPINE1 Proteine).
Data show that protein phosphatase-1 (zeige PPP1CB Proteine) alpha (PP1alpha) is required to maintain checkpoint kinase 1 (CHK1 (zeige CHEK1 Proteine)) in a dephosphorylated state and for the accelerated replication fork progression in Spi1 (zeige SPI1 Proteine)/PU.1 transcription factor-overexpressing cells.
Data suggest that protein phosphatase 1 (zeige PPP1CB Proteine), catalytic subunit, alpha isoform (PPP1CA) is a candidate sero-diagnostic and prognostic marker for badder cancer (BC).
Rif1 (zeige INSL6 Proteine) can mediate MCM dephosphorylation at replication forks and that the stability of dephosphorylated replisomes strongly depends on Chk1 (zeige CHEK1 Proteine) activity.
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (zeige EIF2S1 Proteine) phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (zeige ATF4 Proteine) expression. (eIF2a (zeige EIF2S1 Proteine) = eukaryotic initiation factor-2alpha (zeige EIF2S1 Proteine); PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 (zeige ATF4 Proteine) = activating transcription factor 4 (zeige ATF4 Proteine))
Protein phosphatase 1 (zeige PPP1CB Proteine) (PP1 (zeige PPA1 Proteine)) forms stable complexes with PP1 (zeige PPA1 Proteine)-interacting proteins (PIPs (zeige GPRASP1 Proteine)) that guide the phosphatase throughout its life cycle and control its fate and function.
The authors found that RNA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allosteric mechanism.
this study shows a pivotal role for PP1 (zeige PPA1 Proteine) in impeding IRF7 (zeige IRF7 Proteine)-mediated IFN-alpha (zeige IFNA Proteine) production in host immune responses
The data support a model where Cdc7 (zeige CDC7 Proteine) (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 (zeige CDC7 Proteine) and PP1a/Cdk1 (zeige CDK1 Proteine) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 (zeige GNB1 Proteine) interact in quiescent platelets; then, Ppp1ca and Plcb3 (zeige PLCB3 Proteine) interact during platelet aggregation; thus, Gnb1 (zeige GNB1 Proteine) enlists Ppp1ca to modulate G protein-coupled receptor (zeige GPR34 Proteine) signaling. (Ppp1ca = protein phosphatase 1 (zeige PPP1CB Proteine), catalytic subunit alpha; Gnb1 (zeige GNB1 Proteine) = guanine nucleotide-binding protein (zeige TRIM23 Proteine), subunit beta-1; Plcb3 (zeige PLCB3 Proteine) = phospholipase C (zeige PLC Proteine), subunit beta-3)
Ang IV functions via regulating the activity of PP1
Cell surface expression of the major amyloid-beta peptide (Abeta (zeige APP Proteine))-degrading enzyme, neprilysin (zeige MME Proteine), depends on phosphorylation by mitogen-activated protein kinase (zeige MAPK1 Proteine)/extracellular signal-regulated kinase kinase (MEK (zeige MDK Proteine)) and dephosphorylation by protein phosphatase 1a (zeige PPM1A Proteine).
analysis of selective regulation of NR2B (zeige GRIN2B Proteine) by protein phosphatase-1 (zeige PPP1CB Proteine) for the control of the NMDA receptor in neuroprotection
alteration of lipid rafts is an early event in the apoptotic cascade indirectly induced by interleukin-4 (zeige IL4 Proteine) deprivation via PP1alpha activation, dephosphorylation of cytoplasmic Bad, and caspase (zeige CASP3 Proteine) activation
Data show that Nck (zeige NCK1 Proteine) (isoforms 1 and 2) as a component of the CReP (zeige PPP1R15B Proteine)/PP1c holophosphatase complex contributes to maintain eIF2alpha (zeige EIF2A Proteine) in a hypophosphorylated state, and modulates translation and eIF2alpha (zeige EIF2A Proteine) signaling in response to ER stress.
Our system may be useful for the elucidation of the mechanism of morphological maturation of neuronal cells such as dorsal root ganglion neurons that express SREC-I (zeige SCARF1 Proteine) during early development.
Ppp1ca was identified in the study.
overexpression of two out of five PPP1CA alternative spliced variants reduced tumor cell growth and the downregulation of the protein to hemizygosity increased the anchorage-independent growth
Results demonstrate myofilament regulation by protein phosphatase type 1 alpha and CapZ (zeige CAPZA1 Proteine), and support the concept that cardiac Z-discs are vital components in intracellular signalling.
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
protein phosphatase 1, catalytic subunit, alpha isoform
, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit
, serine/threonine-protein phosphatase PP1-alpha catalytic subunit
, Protein phosphatase type 1 alpha, catalytic subunit
, protein phosphatase-1d
, protein phosphatase 1, catalytic subunit, alpha
, protein phosphatase 1A
, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
, protein phosphatase 2C alpha
, protein phosphatase 2C isoform alpha
, protein phosphatase IA
, PP1 alpha
, protein phosphatase 1 alpha