anti-Human C1S Antikörper für Immunoassay

Recommended C1S Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Complement Component 1, S Subcomponent (C1S) Antikörper
  • AA959438
  • AI255193
  • AI327365
  • C1sa
  • r-gsp
  • C1S
  • complement C1s
  • complement component 1, s subcomponent 1
  • complement component 1, s subcomponent
  • complement component 1, s subcomponent L homeolog
  • complement C1s subcomponent
  • C1S
  • C1s1
  • C1s
  • c1s
  • c1s.L
  • LOC100558615
Reaktivität
Human
135
26
25
5
2
Wirt
Maus
72
60
4
Klonalität
Monoklonal
Konjugat
Dieser C1S Antikörper ist unkonjugiert
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Inhibition Assay (InhA), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
72
61
38
16
15
15
13
8
6
3
3
3
2
1
1
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Produktnummer ABIN2191986
$ 643.71
Zzgl. Versandkosten $45.00

General

Antigen Complement Component 1, S Subcomponent (C1S) Antikörper
Reaktivität Human
(135), (26), (25), (5), (2)
Wirt Maus
(72), (60), (4)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser C1S Antikörper ist unkonjugiert
(4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Inhibition Assay (InhA), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(72), (61), (38), (16), (15), (15), (13), (8), (6), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-C1S Antikörper

Target Details C1S Anwendungsinformationen Handhabung Referenzen für anti-C1S Antikörper (ABIN2191986) Bilder
Sterilität 0.2 μm filtered
Klon M81
Plasmids, Primers & others

Target Details C1S

Produktdetails anti-C1S Antikörper Anwendungsinformationen Handhabung Referenzen für anti-C1S Antikörper (ABIN2191986) Bilder zurück nach oben
Antigen
Andere Bezeichnung c1s (C1S Antibody Abstract)
Hintergrund Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen, MW 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M81 blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.
Pathways Komplementsystem

Anwendungsinformationen

Produktdetails anti-C1S Antikörper Target Details C1S Handhabung Referenzen für anti-C1S Antikörper (ABIN2191986) Bilder zurück nach oben
Applikations-hinweise For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For inhibition of C4 activation by C1s dilutions have to be made according to the amounts C1s to be inactivated.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-C1S Antikörper Target Details C1S Anwendungsinformationen Referenzen für anti-C1S Antikörper (ABIN2191986) Bilder zurück nach oben
Buffer PBS containing 0.1 % bovine serum albumin.
Lagerung 4 °C
Informationen zur Lagerung Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Haltbarkeit 12 months

Referenzen für anti-C1S Antikörper (ABIN2191986)

Produktdetails anti-C1S Antikörper Target Details C1S Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Matsumoto, Nagaki, Kitamura, Kuramitsu, Nagasawa, Seya: "Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 8, pp. 2743-50, 1989