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impact of IL-6 on the Th9/Th17 balance depending on the predominant cytokine milieu; data suggest that the IL-6-mediated reduction of Th2-related IL-4 leads to a decline of the Th9 immune response and allows Th17 differentiation
the results of this study indicate that environmental cues dictate the instability of the Th9 phenotype, and they suggest approaches to enhance Th9 activity in beneficial immune responses
The germinal center development of memory B cells is promoted by follicular helpter T cell-derived IL-9.
In mice, the absence of IL-9 impaired ILC2 proliferation and activation of regulatory T (Treg) cells, and resulted in chronic arthritis with excessive cartilage destruction and bone loss.
These data indicate that IL-9 is an essential regulator of megakaryopoiesis and a promising therapeutic agent for treatment of thrombocytopenia such as CIT (zeige CIT Proteine).
Findings indicate that interleukin-17 (IL-17 (zeige IL17A Proteine)) inhibits the formation of malignant pleural effusion (MPE) and improves the survival of MPE via an interleukin-9 (IL-9)-dependent mechanism.
Group 2 innate lymphoid cells utilize the IRF4 (zeige IRF4 Proteine)-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Our results suggest that The Th9/IL-9 is involved in the pathogenesis of UC.
IL-9 exerted pro-atherosclerotic effects in ApoE (zeige APOE Proteine)-/- mice at least partially by inducing VCAM-1 (zeige VCAM1 Proteine) expression, which mediated inflammatory cell infiltration into atherosclerotic lesions.
IL-9 is dispensable for mucosal mast cell development but is necessary for their effective expansion to promote intestinal mastocytosis and susceptibility to experimental food allergy in an IL-9-dependent autocrine manner.
The systemic IL9 level is higher in ulcerative colitis and corresponds with endoscopic inflammation, suggesting its possible application as a negative marker of mucosal healing.
These findings suggest that IL-9 is involved in the pathogenesis of VKH disease, and that IL-9 might also enhance the inflammatory response by increasing the secretion of IL-17 (zeige IL17A Proteine), an established proinflammatory cytokine in VKH disease
Data suggest that the conditions defined for strong induction of interleukin-9 (IL-9) might be relevant for the development of Vdelta2 T-cell-based immunotherapy. IL-9 might be relevant for the development of Vdelta2 T-cell-based immunotherapy.
expression of IL-9, IFN-gamma and IL-22 was higher in CLP compared to that of OLP
An aberrant expression profile of Th9/IL-9 was associated with pathogenesis of immune thrombocytopenia, possibly through cooperative interaction with Th17/IL-17 (zeige IL17A Proteine).
In vitro data indicate that IL9 is regulated by STAT3 (zeige STAT3 Proteine)/5 and in vivo results highlight the pro-neoplastic effect of IL9 on lymphoma T cells. The results suggest that IL9 and its regulators are promising new targets for therapy development in mycosis fungoides.
recent findings suggest that blockade of IL-9 signaling is effective in treating experimental models of autoimmune and chronic inflammatory diseases such as inflammatory bowel diseases, allergic disorders such as food allergy and asthma.
Findings showed that serum levels of IL-9 were elevated in diffuse large-B-cell lymphoma (DLBCL) patients and positive expression of IL-9 was correlated with adverse prognosis indicators. It directly effected proliferation and apoptosis of DLBCL cells by enhancing the expression of p21CIP1 (zeige CDKN1A Proteine) genes and promoted tumor cells to display resistance to chemotherapeutic drugs.
no differences were found in serum levels of IL-9 between different clinical forms of periportal fibrosis in human Schistosoma mansoni infection in Brazil
PU.1 and IL-9 may play a role in AD pathogenesis and relate to disease severity and clinical eruption types.
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
, T-cell growth factor P40
, cytokine P40
, T-cell growth factor p40
, homolog of mouse T cell and mast cell growth factor 40
, p40 T-cell and mast cell growth factor
, p40 cytokine