Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
we show by molecular replacement that Arg-112 does not participate in binding of IL-11 to its receptors IL-11R and glycoprotein 130 (gp130). Recombinant IL-11 R112H expressed in E. coli displays a correct four-helix-bundle folding topology, and binds with similar affinity to IL-11R and the IL-11/IL-11R/gp130 complex.
SNP rs10940495 in the gp130 locus was associated with functional outcome at 6 months following spontaneous intracerebral hemorrhage.
Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.
gp130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancer.
GP130 signaling is required for tumor cell survival in diverse forms of ALK- anaplastic large cell lymphoma, even in the presence of JAK1 (zeige JAK1 Proteine)/STAT3 (zeige STAT3 Proteine) mutations.
Data show that tumor suppressor adenomatous polyposis coli (APC (zeige APC Proteine)) loss results in up-regulation of IL-6 (zeige IL6 Proteine) signal transducer (IL-6ST/gp130), thereby activating YAP (zeige YAP1 Proteine) (YY1 (zeige YY1 Proteine)-associated) protein (YAP (zeige YAP1 Proteine)) which are simultaneously up-regulated in the majority of colorectal cancer (CRC (zeige CALR Proteine)).
study focused on IL-6 (zeige IL6 Proteine) and activation of its receptors gp80 (zeige CLU Proteine) and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet (zeige FBXL15 Proteine) Kit, Unifast, and Duralay on control of inflammation
an impaired oxidative stress response in hepatocytes with gp130 gain-of-function mutations, as detected in dysplastic intrahepatic nodules and hepatocellular adenomas, is one of the central oncogenic mechanisms in chronic liver inflammation.
The sgp130, IL-6 (zeige IL6 Proteine), and sIL (zeige PMEL Proteine)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 (zeige IL6 Proteine) trans-signaling pathway to the pathophysiology of DR.
This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease.
Genetic ablation of APN (zeige ANPEP Proteine) expression had no effect on infectability by porcine epidemic diarrhea virus, demonstrating that APN (zeige ANPEP Proteine) is not essential for porcine epidemic diarrhea virus cell entry.
pAPN (zeige ANPEP Proteine) is not a functional receptor for porcine epidemic diarrhea virus, but promotes the infection of PEDV through its protease activity.
The C-terminal domain of the S1 domain of porcine epidemic diarrhea virus is bound to swine pAPN (zeige ANPEP Proteine).
Data indicate that fluorogenic substrates can be successfully used to identify aminopeptidase N (zeige ANPEP Proteine) and to measure their activity in cell lysates.
SPC (zeige SFTPC Proteine) subdomain of APN (zeige ANPEP Proteine) plays a key role in cell entry of PEDV and its expression permits PEDV growth
Porcine epidemic diarrhea virus recognizes protein receptor aminopeptidase N (zeige ANPEP Proteine) from pig and human and sugar coreceptor N-acetylneuraminic acid.
These data demonstrate that pAPN (zeige ANPEP Proteine), the cellular receptor for porcine epidemic diarrhea virus, mediates polarized virus infection.
It was concluded that the difference in F4 binding to ANPEP (zeige ANPEP Proteine) is due to modifications in its carbohydrate moieties.
The region aa 673-722 of the C subunit of porcine aminopeptidase N (zeige ANPEP Proteine) is indicated to play a key role in swine transmissible gastroenteritis virus binding.
The binding ability of four truncated porcine aminopeptidase N (zeige ANPEP Proteine) proteins to transmissible gastroenteritis virus (TGEV), a porcine coronavirus, was analyzed by ELISA and immunoblotting.
EBI3 can mediate IL-6 trans-signaling in a process that involves gp130
data suggest that the different sgp130 forms are released from cells into their immediate surroundings and appear to form cell-associated gradients to modulate their own susceptibility for IL-6 (zeige IL6 Proteine) trans-signaling.
Blocking IL-6 (zeige IL6 Proteine) trans-signaling in the CNS abrogates the ability of IL-6 (zeige IL6 Proteine) to suppress feeding. Furthermore, gp130 (zeige LRPPRC Proteine) expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of gp130 (zeige LRPPRC Proteine) in the PVH attenuates the beneficial central IL-6 (zeige IL6 Proteine) effects on metabolism
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Results suggest that the protective role of gp130 (zeige LRPPRC Proteine)-dependent STAT3 (zeige STAT3 Proteine) activation in experimental colitis involves the expansion and activation of mucosal myeloid-derived suppressor cells.
IL-6/gp130 signalling in the osteoclast is not essential for normal bone resorption in vivo, but maintains both trabecular and periosteal bone formation in male mice by promoting osteoblast activity through the stimulation of osteoclast-derived coupling factors and osteotransmitters
gp130 (zeige LRPPRC Proteine)-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin (zeige INS Proteine) resistance.
differences exist in the expression of receptors utilized by the IL-6 (zeige IL6 Proteine)/gp130 (zeige LRPPRC Proteine) family of cytokines in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to oncostatin M (zeige OSM Proteine) by astrocytes versus microglia
Deregulation of gp130 (zeige LRPPRC Proteine)/STAT3 (zeige STAT3 Proteine) signalling augments the acute phase reponse and macrophage infiltration during atherosclerosis without impacting on the development of aortic plaques.
The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
, IL-6 receptor subunit beta
, IL-6R subunit beta
, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
, interleukin receptor beta chain
, interleukin-6 receptor subunit beta
, membrane glycoprotein 130
, membrane glycoprotein gp130
, oncostatin-M receptor subunit alpha
, alanyl aminopeptidase
, aminopeptidase M
, aminopeptidase N
, microsomal aminopeptidase
, interleukin-6 signal transducer
, interleukin 6 signal transducer
, glycoprotein 130
, LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta
, interleukin 6 signal transducer (gp130, oncostatin M receptor)
, interleukin 6 signal transducer receptor