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study focused on IL-6 (zeige IL6 Proteine) and activation of its receptors gp80 (zeige CLU Proteine) and gp130 in human gingival fibroblasts in order to assess the effects of the commercial acid resins Jet (zeige FBXL15 Proteine) Kit, Unifast, and Duralay on control of inflammation
an impaired oxidative stress response in hepatocytes with gp130 gain-of-function mutations, as detected in dysplastic intrahepatic nodules and hepatocellular adenomas, is one of the central oncogenic mechanisms in chronic liver inflammation.
The sgp130, IL-6 (zeige IL6 Proteine), and sIL (zeige PMEL Proteine)-6R concentrations were statistically significantly elevated in patients with diabetic retinopathy (DR), suggesting a probable contributing role of the IL-6 (zeige IL6 Proteine) trans-signaling pathway to the pathophysiology of DR.
This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease.
we developed a CRISPR-Cas9-based tool for specific DNA methylation (zeige HELLS Proteine) consisting of deactivated Cas9 (dCas9) nuclease (zeige DCLRE1C Proteine) and catalytic domain of the DNA methyltransferase (zeige DNMT1 Proteine) DNMT3A (zeige DNMT3A Proteine) targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (zeige HELLS Proteine) of a wider promoter region of the target loci IL6ST and BACH2 (zeige BACH2 Proteine) decreased their expression
data suggest that the different sgp130 forms are released from cells into their immediate surroundings and appear to form cell-associated gradients to modulate their own susceptibility for IL-6 (zeige IL6 Proteine) trans-signaling.
Data indicate possible associations between pretransplant levels of CRP (zeige CRP Proteine)/IL-6 /IL-6 (zeige IL6 Proteine) receptor /gp130 and posttransplant outcomes.
Soluble glycoprotein 130 and hsp27 (zeige HSPB1 Proteine) are novel candidate biomarkers for diagnosing Chronic Heart Failure with preserved ejection fraction and thus warrant further investigation; neither dpp4 (zeige DPP4 Proteine) nor CTSS (zeige CTSS Proteine) showed promise as biomarkers of Chronic Heart Failure.
Intracellular p19 (zeige CDKN2D Proteine) associated with the cytokine receptor (zeige EBI3 Proteine) subunit gp130 and stimulated the gp130-dependent activation of signal transducer and activator of transcription 3 (STAT3 (zeige STAT3 Proteine)) signaling
High serum GP130 levels were associated with Chronic Spontaneous Urticaria.
Genetic ablation of APN (zeige ANPEP Proteine) expression had no effect on infectability by porcine epidemic diarrhea virus, demonstrating that APN (zeige ANPEP Proteine) is not essential for porcine epidemic diarrhea virus cell entry.
pAPN (zeige ANPEP Proteine) is not a functional receptor for porcine epidemic diarrhea virus, but promotes the infection of PEDV through its protease activity.
The C-terminal domain of the S1 domain of porcine epidemic diarrhea virus is bound to swine pAPN (zeige ANPEP Proteine).
Data indicate that fluorogenic substrates can be successfully used to identify aminopeptidase N (zeige ANPEP Proteine) and to measure their activity in cell lysates.
SPC (zeige SFTPC Proteine) subdomain of APN (zeige ANPEP Proteine) plays a key role in cell entry of PEDV and its expression permits PEDV growth
Porcine epidemic diarrhea virus recognizes protein receptor aminopeptidase N (zeige ANPEP Proteine) from pig and human and sugar coreceptor N-acetylneuraminic acid.
These data demonstrate that pAPN (zeige ANPEP Proteine), the cellular receptor for porcine epidemic diarrhea virus, mediates polarized virus infection.
It was concluded that the difference in F4 binding to ANPEP (zeige ANPEP Proteine) is due to modifications in its carbohydrate moieties.
The region aa 673-722 of the C subunit of porcine aminopeptidase N (zeige ANPEP Proteine) is indicated to play a key role in swine transmissible gastroenteritis virus binding.
The binding ability of four truncated porcine aminopeptidase N (zeige ANPEP Proteine) proteins to transmissible gastroenteritis virus (TGEV), a porcine coronavirus, was analyzed by ELISA and immunoblotting.
EBI3 can mediate IL-6 trans-signaling in a process that involves gp130
Blocking IL-6 (zeige IL6 Proteine) trans-signaling in the CNS abrogates the ability of IL-6 (zeige IL6 Proteine) to suppress feeding. Furthermore, gp130 (zeige LRPPRC Proteine) expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of gp130 (zeige LRPPRC Proteine) in the PVH attenuates the beneficial central IL-6 (zeige IL6 Proteine) effects on metabolism
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Results suggest that the protective role of gp130 (zeige LRPPRC Proteine)-dependent STAT3 (zeige STAT3 Proteine) activation in experimental colitis involves the expansion and activation of mucosal myeloid-derived suppressor cells.
IL-6/gp130 signalling in the osteoclast is not essential for normal bone resorption in vivo, but maintains both trabecular and periosteal bone formation in male mice by promoting osteoblast activity through the stimulation of osteoclast-derived coupling factors and osteotransmitters
gp130 (zeige LRPPRC Proteine)-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin (zeige INS Proteine) resistance.
differences exist in the expression of receptors utilized by the IL-6 (zeige IL6 Proteine)/gp130 (zeige LRPPRC Proteine) family of cytokines in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to oncostatin M (zeige OSM Proteine) by astrocytes versus microglia
Deregulation of gp130 (zeige LRPPRC Proteine)/STAT3 (zeige STAT3 Proteine) signalling augments the acute phase reponse and macrophage infiltration during atherosclerosis without impacting on the development of aortic plaques.
The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
, IL-6 receptor subunit beta
, IL-6R subunit beta
, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
, interleukin receptor beta chain
, interleukin-6 receptor subunit beta
, membrane glycoprotein 130
, membrane glycoprotein gp130
, oncostatin-M receptor subunit alpha
, alanyl aminopeptidase
, aminopeptidase M
, aminopeptidase N
, microsomal aminopeptidase
, interleukin-6 signal transducer
, interleukin 6 signal transducer
, glycoprotein 130
, LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta
, interleukin 6 signal transducer (gp130, oncostatin M receptor)
, interleukin 6 signal transducer receptor