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The retinoid x receptor (zeige RXRB Proteine) does not interact with the NR box-1 of ASC-2, but functions as an allosteric activator of LXR (zeige NR1H3 Proteine) binding to NR box-2 of ASC-2.
diverse physiological function of NCOA6 may be mediated by multiple isoforms expressed in different tissues and localized in different subcellular compartments
NCOA6 is responsible for the synergistic activation of CYP2C9 (zeige CYP2C9 Proteine) by HNF4alpha (zeige HNF4A Proteine) and pregnane X receptor (zeige NR1I2 Proteine) and NCOA6 differentially regulates CYP2C9 (zeige CYP2C9 Proteine) and CYP3A4 (zeige CYP3A4 Proteine) gene expression though both the genes are regulated by the same nuclear receptors.
we show that ASC-2 belongs to a steady-state complex of approximately 2 MDa (ASC-2 complex [ASCOM]) in HeLa nuclei. ASCOM contains retinoblastoma-binding protein RBQ-3 (zeige RBBP5 Proteine), alpha/beta-tubulins, and trithorax (zeige MLLT1 Proteine) group proteins ALR-1, ALR-2 (zeige AKR1B1 Proteine), HALR, and ASH2 (zeige ASCL2 Proteine).
The activation of DNA-PK in the absence of DNA ends by the coactivator TRBP suggests a novel mechanism of coactivator-stimulated DNA-PK phosphorylation in transcriptional regulation.
ASC-2 is a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism
ASC-2 appears to contain at least three distinct nuclear receptor interaction domains; also, Rb and ASC-2 have roles in androgen receptor (zeige AR Proteine) transactivation
ASC-2 has a role in inducing target gene transcription during granulocytic differentiation through binding to ATF2 (zeige ATF2 Proteine)
results suggest that ASC-2 is a novel coactivator for HSF1 (zeige HSF1 Proteine) and heat shock stress may contribute to the strong active transcription complex through sequential recruitment of HSF1 (zeige HSF1 Proteine) and ASC-2.
ASC-2 is a bona fide coactivator of the xenobiotic nuclear receptor CAR and mediate the specific xenobiotic response by CAR in vivo.
PRIP deficiency impairs osteoclast differentiation, particularly at the early stages, and PRIP stimulates osteoclast differentiation through calcium-calcineurin-NFATc1 (zeige NFATC1 Proteine) signaling via regulating intracellular Ca(2 (zeige CA2 Proteine)+)
The results suggest that NCOA6 stimulates insulin (zeige INS Proteine) secretion, at least partially, by modulating Nampt (zeige NAMPT Proteine) expression in pancreatic beta-cells.
These results indicate that PRIP is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad (zeige SMAD1 Proteine) phosphorylation, through the methylation of inhibitory Smad6 (zeige SMAD6 Proteine).
The results indicate that PRIP negatively regulates UCP1 (zeige UCP1 Proteine)-mediated thermogenesis in brown adipocytes.
Two independent mouse models of NCOA6 dysfunction develop severe dilated cardiomyopathy with impaired mitochondrial function and reduced activity of peroxisome proliferator-activated receptor delta (zeige PPARD Proteine).
The NCOA6 controls E(2) sensitivity and uterine receptivity by regulating multiple E(2)-signaling components.
ASC-2 negatively affects hepatic insulin (zeige INS Proteine) sensitivity, at least in part, through induction of the insulin (zeige INS Proteine) signalling inhibitors SOCS1 (zeige SOCS1 Proteine) and SOCS3 (zeige SOCS3 Proteine).
PRIP is implicated in the negative regulation of bone formation
methylation of transporter promoters by MLL3 as part of activating signal cointegrator-2 -containing complex is essential for activation of bile salt export pump (zeige ABCB11 Proteine)
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
nuclear receptor coactivator 6
, Nuclear receptor coactivator 6
, NRC RAP250
, PPAR-interacting protein
, activating signal cointegrator 2
, activating signal cointegrator-2
, amplified in breast cancer protein 3
, amplified in breast cancer-3 protein
, cancer-amplified transcriptional coactivator ASC-2
, nuclear receptor coactivator RAP250
, nuclear receptor-activating protein, 250 kDa
, peroxisome proliferator-activated receptor interacting protein
, peroxisome proliferator-activated receptor-interacting protein
, thyroid hormone receptor binding protein
, thyroid hormone receptor-binding protein
, PPAR interacting protein PRIP
, nuclear receptor-activating protein 250
, peroxisome proliferator-activated receptor interacting protein,PRIP