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HEYL rs784621 AA genotype is associated with poor response to therapy in Non-small Cell Lung Cancer.
LSD1 (zeige KDM1A Proteine) directly associates with the promoter of the HEYL gene.
repression of TGFbeta (zeige TGFB1 Proteine) signaling by Notch (zeige NOTCH1 Proteine) acting through HEYL may promote initiation of breast cancer
Repression of androgen receptor (zeige AR Proteine) activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch (zeige NOTCH1 Proteine) effectors.
In this study, we analyzed the effects of HESR1 (zeige HEY1 Proteine), -2, and -3 on DAT1 expression in human neuroblastoma (zeige ARHGEF16 Proteine) SH-SY5Y cells
HeyL null mice do not exhibit an obvious skeletal phenotype demonstrating that HeyL is dispensable for skeletal homeostasis.
These results indicate that Hesr1 (zeige HEY1 Proteine) and Hesr3 are essential for the generation of adult satellite cells and for the maintenance of skeletal muscle homeostasis.
This study demonistrated that HeyL promotes neuronal differentiation of neural progenitor cells by activating proneural genes and by inhibiting the actions of other Hes (zeige ATCAY Proteine) and Hey family members.
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
, class B basic helix-loop-helix protein 33
, hairy-related transcription factor 3
, hairy/enhancer-of-split related with YRPW motif 3
, hairy/enhancer-of-split related with YRPW motif-like protein
, hairy and enhance of split related 3
, hairy and enhancer of split-related protein 3
, basic helix-loop-helix transcription factor heyL