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Human EGLN2 Protein expressed in HEK-293 Cells - ABIN2720027
Lin, Li, Xing, Hu, Liang, Han, Wang, Hawke, Wang, Zhang, Wei, Ma, Park, Zhou, Zhou, Hu, Zhou, Marks, Liang, Hung, Lin, Yang: The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. in Nature cell biology 2016
comparative analysis of phd1, 2, and 3 expression in Xenopus laevis
EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to the progression of triple negative breast cancer.
Selective reduction of PHD1 protein using CRISPR/Cas9 technology reduced both lipid peroxidation and mitochondrial impairment, and attenuated glutamate (zeige GRIN1 Proteine) toxicity in the cultured neurons.
Phd1 deficiency in dendritic cells significantly reduced interleukin-1beta production in response to lipopolysaccharide. Taken together, our results further support the development of selective PHD1 inhibitors for ulcerative colitis, and identify haematopoietic cells as their primary target.
PHD1 deficiency promotes hepatic steatosis and liver-specific insulin (zeige INS Proteine) resistance but does not worsen the deleterious effects of HFD on metabolic homeostasis.
deleting Phd1-3 genes in osteoblasts increased osteoclast formation in vitro and in bone.
These data identify PHD1 as a regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke.
PHD1 and PHD3 (zeige EGLN3 Proteine) deletions promote angiogenesis in ischemia-injured tissue by increasing HIF1-alpha (zeige HIF1A Proteine) stability.
Rosiglitazone increases PHD (zeige PDC Proteine) expression in a PPARgamma (zeige PPARG Proteine)-dependent manner and that this leads to the commitment of anti-adipogenic proteins to the ubiquitination-proteasomal pathway and to the subsequent induction of adipocyte differentiation.
PHD-1 deficient mouse appears to be the first animal model showing neuroepithelial bodies cell hyperplasia
Alterations in the function of all 3 isoforms of prolyl-4-hydroxylase enzymes (PHD1-3) in the first 24 h following transient focal cerebral ischaemia are reported.
In advanced-stage Hodgkin's Lymphoma patients strong cytoplasmic PHD1 expression in Reed-Sternberg cells was associated with poor relapse-free survival among patients treated with involved-field radiotherapy and advanced-stage patients treated with doxorubicin, bleomycin, vinblastine and darcabazine and involved-field radiotherapy.
PHD1 is phosphorylated by CDK2 (zeige CDK2 Proteine), CDK4 (zeige CDK4 Proteine) and CDK6 (zeige CDK6 Proteine) at Serine 130.
siRNA-mediated knockdown of PHD1 inhibited glucose-stimulated insulin (zeige INS Proteine) secretion in pancreatic Beta cells.
EglN2 associates with the NRF1 (zeige NFE2L1 Proteine)-PGC1alpha complex and controls mitochondrial function in breast cancer
rs3733829 in the EGLN2 gene is significantly associated with the risk of COPD (zeige ARCN1 Proteine) in Chinese populations of Hainan province.
Germ-line PHD1 and PHD2 (zeige EGLN1 Proteine) mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia
study conducted to investigate the association between gastric cancer (GC) susceptibility with a 4-bp insertion/deletion polymorphism (rs10680577) in the proximal promoter of EGLN2; findings showed that the heterozygote and the homozygote 4-bp del/del confer a significantly increased risk of GC
Data indicate that the prolyl hydrolase 1 (PHD1) rs10680577 polymorphism is associated with the risk of non-small cell lung cancer in a Chinese population.
PHD-1 played an important role in hypoxic response pathway of trophoblast through modulating the level of HIF-2alpha (zeige EPAS1 Proteine).
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.
EGL nine homolog 2
, egl nine homolog 2
, Egl nine homolog 2
, EGL nine (C.elegans) homolog 2
, egl nine homolog 2 (C. elegans)
, egl nine homolog 2-like
, HIF-prolyl hydroxylase 1
, hypoxia-inducible factor prolyl hydroxylase 1
, immediate early response 4
, prolyl hydroxylase domain-containing protein 1
, HIF-1alpha prolyl-4-hydroxylase-1
, estrogen-induced tag 6