Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human Arrestin 3 Protein expressed in Wheat germ - ABIN1345726
Quack, Woznowski, Potthoff, Palmer, Königshausen, Sivritas, Schiffer, Stegbauer, Vonend, Rump, Sellin: PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia. in The Journal of biological chemistry 2011
These results show that b-arrestin1 (zeige SAG Proteine) and b-arrestin2 exert differential actions on PAC1R (zeige ADCYAP1R1 Proteine) internalization and PAC1R (zeige ADCYAP1R1 Proteine)-dependent ERK1/2 activation, and suggest that the two b-arrestin (zeige SAG Proteine) isoforms may be involved in fine and precise tuning of the PAC1R (zeige ADCYAP1R1 Proteine) signaling pathways.
overexpression of beta-arrestin2 can inhibit the growth of renal cell carcinoma (zeige MOK Proteine) (RCC (zeige XRCC1 Proteine)) cells in vitro, and beta-arrestin2 acts as a tumor suppressor gene in RCC (zeige XRCC1 Proteine); the main mechanism may directly suppress the phosphorylation of IkBa (zeige NFKBIA Proteine) and indirectly suppress NFkB
Study investigated the association between five ARRB2 single nucleotide polymorphisms (SNPs): rs1045280, rs2036657, rs4790694, rs3786047 and rs452246, and response to antidepressant treatment in a sample of 569 patients with a major depressive episode treated for 6months: GG/GT patients for rs4522461 and AA/AC patients for rs4790694 had a lower response.
Itch/beta-arrestin2 complex binds SuFu and induces its Lys63-link (zeige SUFUH Proteine)ed polyubiquitylation without affecting its stability.
These data highlight a novel arrestin (zeige SAG Proteine)-mediated modulation of CREB (zeige CREB1 Proteine) signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR (zeige ADRB2 Proteine) to activate prolonged CREB (zeige CREB1 Proteine) phosphorylation by precluding recruitment of an arrestin2/Src (zeige SRC Proteine)/p38 (zeige CRK Proteine) complex.
A novel regulatory role of GRK2 was proposed for the ubiquitination of beta-arrestin in the context of the PKC-mediated heterologous regulation of GPCRs.
USP33 (zeige USP33 Proteine) may indirectly regulate the degradation and recycling of CXCR4 (zeige CXCR4 Proteine) through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis.
Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced beta-arrestin2 recruitment as compared to displacing radioligand binding from the H1R (zeige HRH1 Proteine).
the internalization motif for the human neuropeptide Y4 receptor, which regulates arrestin-3 recruitment and receptor endocytosis, was identified.
Collectively, these data show that beta-arrestin2 phosphorylation at Thr(383) underlies beta-arrestin-dependent Erk1/2 activation by G protein-coupled receptors.
The fraction of arrestin2 molecules found in clusters larger than 100nm correlates with the magnitude of ligand-induced CCR5 internalization.
K2A mutations in arrestin-1 (zeige SAG Proteine), -2, and -3 significantly reduced their binding to active phosphorhodopsin.
Results reveal that multiple intramolecular interactions coordinately regulate arrestin2 interaction with clathrin, highlighting this interaction as a critical step in regulating receptor trafficking.
Spinal Arrb2 may serve as an intracellular gate for acute to chronic pain transition via desensitization of NMDAR (zeige GRIN1 Proteine).
Knockout of mice beta-arrestin2, but not beta-arrestin1 (zeige ARRB1 Proteine), results in deficits in plasticity mediated by mGlu1 (zeige GRM1 Proteine) receptors in CA3 (zeige CA3 Proteine) pyramidal neurons and by mGlu5 (zeige GRM5 Proteine) receptors in CA1 (zeige CA1 Proteine) pyramidal neurons.
beta-arrestin 2 can protect liver tissue from LPS (zeige TLR4 Proteine)-induced injury via inhibition of TLR4 (zeige TLR4 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signaling pathway-mediated inflammation.
Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of G-protein-coupled receptors.
Arrb2 induces cardiomyocyte death by interacting with the p85 subunit of PI3K, and negatively regulating the formation of p85-PI3K/CaV3 survival complex, thus blocking activation of PI3K-Akt-GSK3beta cell survival signalling pathway in cardiac ischemia-reperfusion.
these results suggest that beta-arrestin2 down-regulation increases hepatocellular carcinoma cell migration and invasion ability
beta-Arrestin2 increases the Itch-mediated ubiquitylation of SuFu (zeige SUFUH Proteine)
Our data reveal beta-arrestin 1 (zeige ARRB1 Proteine), beta-arrestin 2, and AT1R (zeige AGTRAP Proteine) as key regulatory molecules in the Frank-Starling mechanism, which involves length-dependent enhancement of cardiac myofilament Ca(2 (zeige CA2 Proteine)+) sensitivity.
Arrestin (zeige SAG Proteine) beta2 deficiency-mediated intestinal progenitor/stem cell radioprotection relied on protracted NF-kappaB (zeige NFKB1 Proteine) activation and subsequent suppression of PUMA (zeige BBC3 Proteine) induction.
GIP stimulation induces a switch in GIPR recycling from a rapid endosomal to a slow trans-Golgi network (TGN) pathway. GPCR kinases and b-arrestin2 are required for this switch in recycling.
Arrb2 physically interacts with the beta subunit (zeige POLG Proteine) of trimeric G-proteins and Dishevelled (zeige DVL2 Proteine), the interaction between arrb2 and Dishevelled (zeige DVL2 Proteine) is promoted by the beta/gamma subunits of trimeric G-proteins.
results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate hedgehog (zeige SHH Proteine) signaling in zebrafish development
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
arrestin beta 2
, arrestin, beta 2
, arrestin 2
, beta-Arrestin 2
, arrestin beta-2
, arrestin 3
, beta arr2
, beta-arrestin 2