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Inhbaa functions as a cardiomyocyte mitogen and that its overexpression leads to accelerated cardiac recovery and scar clearance after injury.
The present study demonstrated that EGF controlled expression of three activin subunits (inhbaa, inhbab and inhbb) in the follicle cells via diverse signaling pathways.
the hCG-stimulated activin betaA expression is dependent on the activation of the cAMP-PKA pathway
Activin betaA is involved in promoting ovary and follicle growth, whereas activin betaB may have a tonic role throughout follicle development but becomes critical at the late stage of oocyte maturation and/or ovulation.
Activin signaling through SMAD2/3 in retinal progenitor cells regulates expression of transcription factors involved in cell type determination and promotes photoreceptor lineage specification.
Our study provided experimental and clinical evidence for the involvement of activin A and ALK4 in the pathophysiology of atrial fibrosis and atrial fibrillation
binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin activity, rather than hormonal dysregulation.
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells.
ENPP2 links Activin-A enhanced mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
Mice with elevated levels of IL6 exhibited 8.1% weight loss after 9 weeks, whereas mice with elevated levels of activin A lost 11% of their body weight
a conserved role for activin in enhancing adipokinetic hormone/glucagon signaling and glycemic control, is reported.
Results indicate that activin betaA has an important role outside of reproduction and development, specifically in digestion.
Activin A protects midbrain neurons in the 6-hydroxydopamine mouse model of Parkinson's disease.
BMP-4 increases activin A gene expression during mouse ES cell differentiation into bone precursors
This study assesses the regulation of activin A and follistatin in a murine myocardial ischaemia-reperfusion model.
the Activin/ALK4 pathway directly recruits PTP1B and stimulates its release from the endoplasmic reticulum through ALK4-mediated cleavage.
Data indicate that mice injected with increasing doses of rAAV6:activin A exhibited weight loss in a dose-dependent manner.
medulla projection neurons lacking Activin signaling expanded their dendritic fields and aberrantly synapsed with neighboring photoreceptors
Both moderate and severe hypoxia are consistently associated with normal or even reduced levels of activin betaA (Inhba) mRNA. Unexpectedly, hypoxia alone does not cause increased activin A recruitment as a neuroprotective agent.
retinoid signalling can potently suppress activin-induced proliferation by antagonising G1 phase progression and entry into the cell cycle.
Eda and activin A are upstream regulators of Foxi3 in skin appendage placodes
Report role of activin A-myostatin-follistatin system on aging bone and muscle progenitor cells.
nodal/activin-A acts downstream of fibroblast growth factor signaling to promote male germ cell fate and protect somatic cells from initiating female differentiation
This finding suggests that blockade of activin A signalling in ischaemic tissue may improve preservation of the affected tissue.
Low INHBA expression is associated with diffuse large B-cell lymphoma.
pro-activin A share features seen in the pro-TGF-beta1 and pro-BMP-9 structures.
Data suggest that activin A (INHBA) plays roles in inflammation, tissue repair, fibrosis, neoplastic activation of myofibroblasts, and leiomyoma development/growth. [REVIEW]
that high expression of INHBA was associated with poor response to therapy for de novo AML, and it can serve as an adverse prognostic factor for this malignancy.
Activin-A may induce fibrosis in NASH and alcoholic cirrhosis via activation of Kupffer cells to express pro-inflammatory molecules that promote HSC-dependent fibrogenesis and could be a target for future anti-fibrotic therapies.
INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1.
Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. (Review)
The present study was undertaken to evaluate the distribution of the FSHB -211 G/T in men with normal or abnormal sperm parameters from Southern Italy to assess its functional relevance on the serum levels of reproductive hormones and on sperm parameters in men.
analysis of a novel SMAD-independent pathway linking enhanced activin B signaling to reduced E-cadherin expression and increased migration in type II endometrial cancer
High INHBA expression is associated with lung adenocarcinoma.
activin A signaling has a role in melanoma growth and metastasis through immune evasion
These data provide evidence that eosinophils release activin A and that this function is enhanced when eosinophils are present in an allergen-induced inflammatory environment.
These results demonstrate that activin induces skin carcinogenesis via attraction and reprogramming of macrophages and identify novel activin targets involved in tumor formation.
our results defined a novel pathway in which dysregulation of the RUNX2/INHBA axis due to miR-376c downregulation fosters lymph node metastasis in head and neck squamous cell carcinoma
The activin-A to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes.
A screen of a human protein library identified activin A as a potent regulator of follicular helper T cells cell differentiation.
Activin A is higher in patients with steatohepatitis than both lean and obese controls
Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.
The expression of the components of the activin-inhibin-follistatin system is altered in bovine cystic ovarian disease.
Results support a physiological role for granulosa-derived inhibin as an antagonist of bone morphogenetic protein action on thecal androgen synthesis.
activin AB is a lignd for activin type IB receptor ALK7 and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6.
An increased expression of Inhibin-beta A was found in oocytes collected from large and medium follicles compared with small follicles before or after in oocyte vitro maturation.
INHA and INHB expression and cellular localization in porcine oocytes were studied.
results indicated that boar testis produces inhibin A and inhibin B during the infantile period but inhibin A is the predominant form towards puberty and molecular weight forms of inhibin and the sites of production change with testicular development
This is the first report on INHBA as an associated candidate gene with the LSM of stallions and the paternal and embryonic component of BVs for the pregnancy rate per oestrus.
The result showed that AA genotype had remarkable litter size at P1 locus in the three goat breeds (P < 0.05). Therefore, these results suggest that INHA gene is a strong candidate gene that affects litter size in goats.
Sequence comparison showed that three base changes in INHA(two amino acid substitutions), and three base changes in INHBA,(one amino acid substitution). No difference seen in INHA or INHBA mRNA expression level in the follicle of the two goat breeds.
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
inhibin, beta A
, activin beta A
, activin beta A1
, inhibin beta A
, inhibin, beta A (activin A, activin AB alpha polypeptide)
, activin A
, inhibin beta A chain-like
, activin beta-A chain
, inhibin beta A chain
, FSH-releasing protein
, Inhibin, beta-1
, erythroid differentiation factor
, erythroid differentiation protein
, follicle-stimulating hormone-releasing protein
, inhibin beta-subunit
, inhibin beta A subunit
, inhibin beta-A-subunit