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KAP plays an essential role in Kinesin II function, which is required for the axoneme growth and maintenance of the cilia in Drosophila type I sensory neurons.
Data suggest that Kap participates in the transport of signalling components required for instructive interactions between germline and soma cells.
Observations suggest that KAP stabilizes the motor subunit heterodimer and help assemble a greater kinesin-2 complex in vivo.
This study does not show an influence of KIFAP3 variants on survival in the studied Swiss and Swedish cohort
These data suggest that GLI interactions with KIF3A-KIF3B-KAP3 complexes are essential for proper GLI transcriptional activity.
Common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients.
The incidence of the motor neuron-predominant amyotrophic lateral sclerosis phenotype in the patients of this cohort supports the hypothesis that the SNP within the KIFAP3 gene is a potential modifier of the amyotrophic lateral sclerosis phenotype
Data clearly show that SNP rs1541160 does not modify survival within cohort of 504 Italian ALS cases.
Required for the normal steady-state localization of late endosomes/lysosomes but not early endosomes or recycling endosomes.
Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis.
Kinesin-2 plays a role in the KDEL-R-/COPI-dependent retrograde transport pathway from the Golgi complex to the ER.
KAP3 sequestration by misfolded SOD1 and the inhibition of ChAT transport play a role in the dysfunction of amyotrophic lateral sclerosis.
a variant within the KIFAP3 gene that is associated with decreased KIFAP3 expression and increased survival in sporadic ALS was identified.
SOD1 associates specifically KAP3 in the ventral white matter of SOD1 transgenic mouse.
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras\; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.
, Kinesin-associated protein 3
, kinesin II accessory protein
, kinesin accessory protein
, kinesin associated protein 3
, small G protein GDP dissociation stimulator
, smg GDS-associated protein
, Smg GDS
, LOW QUALITY PROTEIN: kinesin-associated protein 3
, kinesin-associated protein 3
, kinesin-associated protein 3 L homeolog