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intraflagellar transport protein 20 (IFT20) interacts with E3 ubiquitin ligases c-Cbl and Cbl-b and is required for Cbl-mediated ubiquitination and internalization of PDGFRalpha for feedback inhibition of receptor signaling.
IFT20 is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.
This work is a strong support of a model of opsin transport where IFT20 is involved in the movement from the Golgi complex to the base of the cilium
Mxi1 regulates Ift20 promoter activity via Ets-1 binding to the Ift20 promoter. These results indicate that inactivating Mxi1 induces ciliary defects in polycystic kidney.
Data show that loss of IFT20 during cone development leads to opsin accumulation in the inner segment even when the connecting cilium and outer segment are still intact.
An interaction between SPEF2 and the intraflagellar transport protein IFT20 in the testis.
This work suggests that IFT20 functions in the delivery of ciliary membrane proteins from the Golgi complex to the cilium.
IFT20 functions to couple extracellular events to cell proliferation and differentiation and deletion results in cystic kidney diseease.
GMAP210 and IFT20 function together at the Golgi in the sorting of proteins destined for the ciliary membrane.
IFT20 is the only complex B protein that localizes to the Golgi apparatus.
the traffic-related role of an IFT20 complex that includes components of the intracellular trafficking machinery in immune synapse assembly, is reported.
Data report the molecular cloning and characterization of a novel human cDNA encoding a putative protein of 158 amino acid residues which shares high homology to Mus musculus intraflagellar transport protein mIFT20.
IFT20 is an intraflagellar transport protein that appears to bridge kinesin II with the IFT complex.
This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.
intraflagellar transport 20 homolog
, intraflagellar transport protein 20 homolog
, uterine protein
, intraflagellar transport protein IFT20