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Hhat plays a critical role in ER positive, HER2 amplified, and hormone resistant breast cancer proliferation.
Data suggest that substrate specificity of hedgehog acyltransferase (HHAT) in palmitoylation reaction extends to oligopeptide fragments of Sonic hedgehog protein (SHH).
three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides.
analysis of hedgehog acyltransferase membrane topology
provide the first clinical evidence of the essential role played by lipid modification of Hh proteins in human testicular organogenesis and embryonic development
rs7527939 is the strongest indicator of susceptibility to schizophrenia in the Bulgarian population within the HHAT locus.
SKN is necessary for the proliferation of the non-small cell lung carcinoma cells
These findings define residues and regions within Shh that are necessary for its recognition as a substrate for Hhat-mediated palmitoylation.
SKI-1/S1P activity is thus essential for hepatitis C virus production and its inhibition should be considered for antiviral drug development.
Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.
Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).
protein-cysteine N-palmitoyltransferase HHAT
, hedgehog acyltransferase
, protein-cysteine N-palmitoyltransferase HHAT-like
, melanoma antigen recognized by T cells 2
, melanoma antigen recognized by T-cells 2
, skinny hedgehog protein 1
, skinny hedgehog protein