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Human HTRA1 Protein expressed in Escherichia coli (E. coli) - ABIN368668
Frochaux, Hildebrand, Talke, Linscheid, Schlüter: Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. in PLoS ONE 2014
HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels.
Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.
Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR of ARMS2 (zeige ARMS2 Proteine) to be associated with drusen.
As in humans, one variant within LOC387715/ARMS2 (zeige ARMS2 Proteine) and one in HTRA1 were significantly associated with age-related macular degeneration.
Results suggest that HTRA1 is involved in the pathogenesis of scars through regulating activation of latent TGF-beta1 (zeige TGFB1 Proteine) in keloid fibroblasts.
the CADASIL (zeige NOTCH3 Proteine)-like family disease may be caused by heterozygous HTRA1 gene mutation, which leads to autosomal dominant hereditary cerebral small vessel disease.
Case Report/Review: novel missense mutation in HTRA1 associated with phenotype of CARASIL.
The rs11200638-rs2672598 joint genotype AA-CC conferred higher risk to exudative exudative age-related macular degeneration (AMD (zeige AMD1 Proteine)) than polypoidal choroidal vasculopathy (PCV).
a possible proteolytic processing mechanism of mutant TGFBIp by HTRA1 and peptides generated by mutant protein may form the beta-amyloid core of corneal aggregates in Corneal dystrophic patients.
HtrA1 Proteolysis of ApoE (zeige APOE Proteine) In Vitro Is Allele Selective
The observation of this study further supports the pathogenic role of the heterozygous HTRA1 mutations in familial cerebral small vessel disease.
These findings suggest that the variation in the risk for age-related macular degeneration associated with chromosome 10q26 is likely due to variation in HTRA1 expression.
HtrA1 role in the cisplatin resistance in colon cancer
HtrA1 could serve as a marker to identify ulcerative colitis of >10 year duration patients at high risk of developing colorectal cancer.
transfection of cells with a constitutively active rapamycin-resistant p70S6K (zeige RPS6KB1 Proteine) mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.
Increased expressions of Tgf-beta1 (zeige TGFB1 Proteine), p-Smad2 (zeige SMAD2 Proteine)/3 and HtrA1 were detected in the articular chondrocytes of knee joints in models of osteoarthritis.
In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta (zeige TGFB1 Proteine) pathway activation.
HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone
The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD (zeige AMD1 Proteine)
the inhibitory effect of IFN-gamma (zeige IFNG Proteine) on HTRA1 expression was evidenced in collagen-induced arthritis (CIA (zeige NCOA5 Proteine)) mouse models and in human RA synovial cells.
Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.
Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (zeige BMP2 Proteine)-induced Smad1 (zeige SMAD1 Proteine)/5/8, ERK1/2 and p38 (zeige CRK Proteine) phosphorylation in pre-osteoblasts.
This study offers new insights into the regulation of HTRA-1 expression via LPS (zeige TLR4 Proteine)/TLR-4 (zeige TLR4 Proteine) and the role of HTRA-1 in rheumatoid arthrisis pathogenesis.
suggest a critical role for LRP1 (zeige LRP1 Proteine) in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor (zeige CTGF Proteine) protein levels.
The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound Fibroblast Growth Factors (FGF) ligands and stimulates long-range FGF signaling.
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
HtrA serine peptidase 1
, high-temperature requirement A serine peptidase 1A
, serine protease 11
, serine protease HTRA1A
, high-temperature requirement A serine peptidase 1B
, serine protease HTRA1B
, high temperature required A1
, Serine protease HTRA1
, high-temperature requirement A serine peptidase 1
, protease, serine, 11 (IGF binding)
, serine protease HTRA1
, insulin-like growth factor binding protein 5 protease
, protease, serine, 11 (Igf binding)
, IGF binding
, protease, serine, 11
, protease serine 11
, High-temperature requirement A serine peptidase 1
, Serine protease 11