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anti-Mouse (Murine) Fibromodulin Antikörper:
anti-Rat (Rattus) Fibromodulin Antikörper:
anti-Human Fibromodulin Antikörper:
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Human Polyclonal Fibromodulin Primary Antibody für WB - ABIN515774
Yang, Culshaw, Liu, Lu, French, Clements, Corcoran: Canine tissue-specific expression of multiple small leucine rich proteoglycans. in Veterinary journal (London, England : 1997) 2012
Human Polyclonal Fibromodulin Primary Antibody für WB - ABIN4311712
Herchenhan, Uhlenbrock, Eliasson, Weis, Eyre, Kadler, Magnusson, Kjaer: Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells. in The Journal of biological chemistry 2015
Studies in knockout, obese, and diabetic mouse models helped characterize the operation of a novel FMOD-based regulatory circuit that controls myoblast switching from a myogenic to a lipid accumulation fate. FMOD regulation of myoblasts is an essential part of the myogenic program, and it offers opportunities for the development of therapeutics for the treatment of different muscle diseases
impact of FMOD deficiency on the development of experimental skin fibrosis is limited
Fibromodulin can be a unique effector of dense collagen matrix assembly in tumor stroma and, without affecting other major matrix components or the cellular composition, can function as a main agent in tumor barrier function
The data suggest a fibromodulin-modulated collagen cross-linking mechanism where fibromodulin binds to a specific part of the collagen domain and also forms a complex with lysyl oxidase (zeige LOX Antikörper), targeting the enzyme toward specific cross-linking sites.
Suggest a more complex role for collagen in plaque stability than previously anticipated in fibromodulin-deficient/ApoE (zeige APOE Antikörper)-null atherosclerotic mice.
Hepatic fibromodulin activates hepatic stellate cells and promotes collagen I deposition, which leads to liver fibrosis.
The differential effects of Fmod deficiency on bones and teeth appear to diverge in adult mice.
Fibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA (zeige NFKBIA Antikörper) via a JNK (zeige MAPK8 Antikörper)-dependent pathway coupled to fibroblast apoptosis.
FMOD presence is critical for proper temporospatial coordination of wound healing events and normal TGF-beta (zeige TGFB1 Antikörper) bioactivity.
fibromodulin plays important roles in the regulation of region-specific fibrillogenesis required for the integration of the corneal and scleral matrices and sulcus development required for establishment of the visual axis
Some nine tyrosine residues in the fibromodulin N-terminal domain are O-sulfated (zeige SULF1 Antikörper), a posttranslational modification often involved in protein interactions. Taken together, this study suggests a novel, regulatory function for tyrosine sulfation in Fibromodulin, which controls the interaction with collagen type I.
There are discrete populations of fibromodulin within articular cartilage, which may have differing impacts upon tissue processes.
MMP-13 (zeige MMP13 Antikörper) treatment of fresh articular cartilage results in cleaved fibromodulin fragments
fibromodulin and decorin (zeige DCN Antikörper) have similarities and differences that may represent the biochemical basis of redundancy in small leucine-rich proteoglycan (zeige Vcan Antikörper) function
tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin (zeige OMD Antikörper) bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors
crystal structures at ~2.2A resolution of human fibromodulin and chondroadherin (zeige CHAD Antikörper).
we found that secreted FMOD as an important regulator of glioma cell migration downstream of TGF-beta1 (zeige TGFB1 Antikörper) pathway and forms a potential basis for therapeutic intervention in GBM.
The small leucine rich proteoglycan (zeige Vcan Antikörper) fibromodulin is overexpressed in human prostate epithelial cancer cell lines in culture and human prostate cancer tissue.
fibromodulin is involved in the inflammatory processes that characterize atherosclerotic plaque vulnerability
The results suggest that regions within FMOD is associated with ACL (zeige ACLY Antikörper) injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.
Melanocyte-secreted factor FMOD is a key regulator of angiogenesis.
lumican (zeige LUM Antikörper) and fibromodulin display different behaviors and that lumican (zeige LUM Antikörper) may promote regeneration of the TMJ after degeneration and deformation induced by IL-1 beta (zeige IL1B Antikörper).
study shows (1) a detailed description of ectopic ossification (EO) formed by Bgn (zeige BGN Antikörper), Fmod or combined depletion, (2) the role of exercise in modulating EO and (3) that Bgn (zeige BGN Antikörper) and Fmod are critical in controlling motor function.
Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix.
, KSPG fibromodulin
, collagen-binding 59 kDa protein
, keratan sulfate proteoglycan fibromodulin