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anti-Human Neuromedin U Antikörper:
anti-Mouse (Murine) Neuromedin U Antikörper:
anti-Rat (Rattus) Neuromedin U Antikörper:
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NMU might contribute to progression of NMUR2 (zeige NMUR2 Antikörper)-positive breast cancer
The anti-tumorigenic effect of HAND2 (zeige HAND2 Antikörper)-AS1 (zeige PTGDR Antikörper) in endometrioid endometrial carcinoma was mediated by down-regulating neuromedin U expression.
Results indicate a mechanism of action for neuromedin U (NmU) in HER2 (zeige ERBB2 Antikörper)-overexpressing breast cancer that enhances resistance to HER2 (zeige ERBB2 Antikörper)-targeted drugs through conferring cancer stem cell (CSC) characteristics and expansion of the CSC phenotype.
This study shows an association between a NMU haplotype and anthropometric indices, mainly linked to fat mass, which appears to be age- and sex-specific in children.
Overexpression of Nmu may be involved in the process of regional metastasis of HNSCC, and may serve as a novel and valuable biomarker for predicting regional metastasis in patients with HNSCC.
our results defined NmU as a candidate drug response biomarker for HER2 (zeige ERBB2 Antikörper)-overexpressing cancers and as a candidate therapeutic target to limit metastatic progression and improve the efficacy of HER-targeted drugs.
a role for NMU gene through interaction with ADRB2 (zeige ADRB2 Antikörper) gene in bone strength regulation
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.
[review] Taken together with its vascular actions, NMU may be a functional link between energy balance and the cardiovascular system and may provide a future target for therapies directed against the disorders that comprise metabolic syndrome.
These results suggest that NMU plays a role in feeding behavior and catabolic functions via corticotropin-releasing hormone (zeige CRH Antikörper).
These data indicate a novel role for the peripheral NMU system, providing new insights into the pathogenesis of NAFLD (zeige TSC2 Antikörper)/NASH (zeige SAMSN1 Antikörper).
Loss of NMU-NMUR1 (zeige NMUR1 Antikörper) signalling reduced ILC2 frequency and effector function, and altered transcriptional programs following allergen challenge in vivo. Thus, NMUR1 (zeige NMUR1 Antikörper) signalling promotes inflammatory ILC2 responses, highlighting the importance of neuro-immune crosstalk in allergic inflammation at mucosal surfaces.
data indicate that the NMU-NMUR1 (zeige NMUR1 Antikörper) neuronal signaling circuit provides a selective mechanism through which the enteric nervous system and innate immune system integrate to promote rapid type 2 cytokine responses that can induce anti-microbial, inflammatory and tissue-protective type 2 responses at mucosal sites
NMU treatment in vivo resulted in immediate protective type 2 responses; accordingly, group 2 innate lymphoid cells -autonomous ablation of Nmur1 (zeige NMUR1 Antikörper) led to impaired type 2 responses and poor control of worm infection
These results suggested that NMU can act directly on beta cells through NMUR1 (zeige NMUR1 Antikörper) in an autocrine or paracrine fashion to suppress insulin (zeige INS Antikörper) secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin (zeige INS Antikörper) secretion, and may improve our understanding of glucose homeostasis.
These results suggest that NMU and NMS (zeige NMS Antikörper) are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS (zeige NMS Antikörper) might play a more predominant role than NMU.
the anorectic effect of the lipidated NMU is partly mediated by a decrease in gastric emptying which is subject to tachyphylaxis after continuous dosing.
Beta-adrenergic and cholinergic mechanisms are involved in the anxiolytic action of neuromedin-U.
Data show that neuromedin U (NMU)-deficient mice developed less severe arthritis than control mice.
investigation of neuromedin U effects on factors associated with obesity/diabetes: NMU reduced food consumption/body weight; NMU increased body temperature/metabolic rate; NMU improved glucose tolerance; these effects seem to be mediated by NMUR1 (zeige NMUR1 Antikörper)
These results reveal an unexpected functional and anatomical interface between the Nmu system and brainstem arousal systems that represents a novel wake-promoting pathway.
NMU mRNA was expressed both in the central nervous system (CNS) and in peripheral tissues
may induce uterine smooth muscle contraction and selective vasoconstriction
, neuromedin U