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Activation of DPF3a upon hypertrophic stimuli in cardiac hypertrophy switches cardiac fetal gene expression from being silenced by HEY to being activated by BRG1 (zeige SMARCA4 Proteine).
identified and characterized human HES (zeige RRBP1 Proteine)-like (HESL), rat hesl, and rainbow trout hesl genes by using bioinformatics
the combination of gain- and loss-of-function experiments in the developing midbrain showed co-operative roles for Mgn and Mash1 (zeige ASCL1 Proteine) genes in determining GABAergic identity.
the prethalamic factors Dlxs upregulated by Ascl1 (zeige ASCL1 Proteine)/Helt deficiency play unique roles in regulating thalamic progenitor specification.
Helt acts as a transcriptional repressor to regulate neuronal differentiation and/or identity
identification of a novel mouse bHLH factor, termed Heslike, that has Hes1 (zeige HES1 Proteine)-like bHLH domain and transcriptional repressor activity; Heslike is coexpressed with the bHLH factor Mash1 (zeige ASCL1 Proteine) in brain regions that give rise to GABAergic neurons
Mgn is a single copy gene on mouse chromosome 8 and encodes a 27kDa (zeige HSPB1 Proteine) protein that functions in the nucleus.
Homozygous Mgn-null mice die between the second and the fifth postnatal week of age, and show a complete depletion of Gad65 (zeige GAD2 Proteine) and Gad67 (zeige GAD1 Proteine) expression in the superior colliculus and a reduction in the inferior colliculus.
Helt determines GABAergic over glutamatergic fate, by repressing Ngn (zeige NEUROG1 Proteine) genes; Helt and Ngns are commonly used in the mesencephalon for determination of the GABAergic versus glutamatergic transmitter phenotype.
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3' (By similarity).
HES/HEY-like transcription factor
, Hey-like transcription factor
, Hey-like transcriptional repressor
, Megane bHLH factor
, hairy and enhancer of split-related protein HELT
, bHLH transcription factor megane
, mesencephalic GABAergic neurons enhancer of split related protein
, protein megane
, HES/HEY-like transcription factor, pseudogene 1
, Her/Hey-like protein
, hairy and enhancer of split-related protein helt