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study proposes that Trb3 governs left-right (LR) axis patterning as a component of TGF-signaling in embryonic development
A link between TRIB3 and the stereotypical pattern of gray matter loss in Alzheimer's disease.
the R141 site of TRIB3 dictates the strength of Akt (zeige AKT1 Proteine) binding but does not affect other Trbl-dependent developmental processes, suggesting a specificity that could serve as a drug target for metabolic diseases.
TRB3 is overexpressed in lesions of patients with psoriasis.
tribbles (zeige TRIB1 Proteine) pseudokinase 3 (TRB3) and sestrin 2 (zeige SESN2 Proteine) may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity
TRIB3, a single-domain protein with impaired kinase catalytic activity, has been described to perform a complex of roles, many of which are likely to be cell type-specific. (Review)
High TRB3 expression is associated with basal-like breast cancer.
TRIB3 promotes acute promyelocytic leukemia (zeige PML Proteine) progression through stabilization of the oncoprotein PML (zeige PML Proteine)-RARalpha (zeige RARA Proteine) and inhibition of p53 (zeige TP53 Proteine)-mediated senescence.
Downregulation of TRIB3 is associated with lung cancer.
This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E (zeige SEMA3E Proteine) and what effect semaphorin 3E (zeige SEMA3E Proteine) exerts on carotid atherosclerosis.
overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with gastric cancer (GC) . Our findings indicate that TRIB3 is a promising target for antiangiogenic therapy in GC.
Overexpressed Trib3, specifically in skeletal muscle tissues, displayed impaired glucose homeostasis by suppressing insulin (zeige INS Proteine)-stimulated glucose uptake.
under nutrient-limiting conditions that stimulate ATF4 (zeige ATF4 Proteine) activity, TRIB3 is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21 (zeige FGF21 Proteine).
Data (including data from studies in transgenic and mutant mice) suggest that Akt2 (zeige AKT2 Proteine) plays critical role in type 1 diabetes in metallothionein (zeige MT Proteine)-mediated preservation of cardiac insulin (zeige INS Proteine)-stimulated metabolic signaling (insulin (zeige INS Proteine) resistance) and preservation of cardiac function; this mechanism appear to involve inhibition of cardiac Trb3. (Akt2 (zeige AKT2 Proteine) = protein kinase Akt-2 (zeige AKT2 Proteine); Trb3 = tribbles (zeige TRIB1 Proteine) pseudokinase 3)
restoration of TRB3 expression markedly abolished the effect of miR (zeige MLXIP Proteine)-124 on hepatic TG metabolism.
TRB3 regulates protein synthesis and breakdown via the Akt (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine)/FoxO (zeige FOXO3 Proteine) pathways in skeletal muscle.
Chac1 (zeige CHAC1 Proteine) expression is detrimental to arsenite-treated cell survival and TRIB3 is critical for restraining the pro-death potential of Chac1 (zeige CHAC1 Proteine) during arsenite stress.
Under physiological conditions, muscle TRIB3 also influences energy expenditure and substrate metabolism, indicating that the decrease and increase in muscle TRIB3 under fasting and nutrient excess, respectively, are critical for metabolic homeostasis.
In a knockout mouse model, Trib3 disruption modestly increased steady-state erythrocyte numbers and decreased mean corpuscular volume.
Palmitate increased TRB3 expression, activated IRE1alpha (zeige ERN1 Proteine) signaling, and reduced the insulin (zeige INS Proteine)-dependent Akt (zeige AKT1 Proteine) phosphorylation. Knocking down TRB3 or IRE1alpha (zeige ERN1 Proteine) did not prevent the inhibitory effect of palmitate on Akt (zeige AKT1 Proteine) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.
This work aimed to study the porcine tribbles homolog 3 (TRIB3) gene and to evaluate its association with meat quality and carcass traits in pigs.
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.
tribbles homolog 3
, tribbles homolog 3 (Drosophila)
, tribbles homolog 3-like
, neuronal cell death inducible putative kinase
, neuronal cell death-inducible putative kinase
, p65-interacting inhibitor of NF-kappa-B
, p65-interacting inhibitor of NF-kappaB
, induced in fatty liver dystrophy 2
, Neuronal cell death Inducible Putative Kinase
, tribbles 3