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study proposes that Trb3 governs left-right (LR) axis patterning as a component of TGF-signaling in embryonic development
TRIB3, a single-domain protein with impaired kinase catalytic activity, has been described to perform a complex of roles, many of which are likely to be cell type-specific. (Review)
High TRB3 (zeige TAS2R13 ELISA Kits) expression is associated with basal-like breast cancer.
TRIB3 promotes acute promyelocytic leukemia (zeige PML ELISA Kits) progression through stabilization of the oncoprotein PML (zeige PML ELISA Kits)-RARalpha (zeige RARA ELISA Kits) and inhibition of p53 (zeige TP53 ELISA Kits)-mediated senescence.
Downregulation of TRIB3 is associated with lung cancer.
This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E (zeige SEMA3E ELISA Kits) and what effect semaphorin 3E (zeige SEMA3E ELISA Kits) exerts on carotid atherosclerosis.
overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with gastric cancer (GC) . Our findings indicate that TRIB3 is a promising target for antiangiogenic therapy in GC.
Our findings suggest that good glucose and blood pressure control exhibited greater benefits on vascular outcomes in patients with TRIB3 (rs2295490) G allele.
In this exploratory analysis, IRS1 (zeige IRS1 ELISA Kits), ENNP1 and TRIB3, known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (zeige INS ELISA Kits) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.
TRIB3 acts as a crucial 'stress adjusting switch' that links homeostasis, metabolic disease and cancer; and is being actively investigated as a disease biomarker and therapeutic target
TRB3 (zeige TAS2R13 ELISA Kits) is upregulated in macrophages upon treatment with ox-LDL. TRB3 (zeige TAS2R13 ELISA Kits) promotes lipid accumulation and suppresses cytokine expression, suggesting inflammation and foam cell formation can be reciprocally regulated.
TRB3 regulates protein synthesis and breakdown via the Akt (zeige AKT1 ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits)/FoxO (zeige FOXO3 ELISA Kits) pathways in skeletal muscle.
Chac1 expression is detrimental to arsenite-treated cell survival and TRIB3 is critical for restraining the pro-death potential of Chac1 during arsenite stress.
Under physiological conditions, muscle TRIB3 also influences energy expenditure and substrate metabolism, indicating that the decrease and increase in muscle TRIB3 under fasting and nutrient excess, respectively, are critical for metabolic homeostasis.
In a knockout mouse model, Trib3 disruption modestly increased steady-state erythrocyte numbers and decreased mean corpuscular volume.
Palmitate increased TRB3 expression, activated IRE1alpha (zeige ERN1 ELISA Kits) signaling, and reduced the insulin (zeige INS ELISA Kits)-dependent Akt (zeige AKT1 ELISA Kits) phosphorylation. Knocking down TRB3 or IRE1alpha (zeige ERN1 ELISA Kits) did not prevent the inhibitory effect of palmitate on Akt (zeige AKT1 ELISA Kits) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.
These data demonstrate that TRB3 inhibits insulin (zeige INS ELISA Kits) signaling in BAT (zeige BAAT ELISA Kits), resulting in impaired differentiation and function.
TRB3 is a novel profibrotic mediator in SSc (zeige CYP11A1 ELISA Kits). TGF-beta (zeige TGFB1 ELISA Kits) induces TRB3, which in turn activates canonical TGF-beta (zeige TGFB1 ELISA Kits)/Smad (zeige SMAD1 ELISA Kits) signaling and stimulates the release of collagen, creating a positive feedback loop that may contribute to aberrant TGF-beta (zeige TGFB1 ELISA Kits) signalling in SSc (zeige CYP11A1 ELISA Kits).
study presents the finding that activation of the NF-kappaB (zeige NFKB1 ELISA Kits) pathway by Porphyromonas endodontalis LPS (zeige TLR4 ELISA Kits) is important for Wnt5a (zeige WNT5A ELISA Kits) expression in osteoblasts, and that TRIB3 may modulate the sustained expression of Wnt5a (zeige WNT5A ELISA Kits) in osteoblasts stimulated by P. endodontalis
TRIB1 (zeige TRIB1 ELISA Kits) and TRIB3 are more strongly expressed than TRIB2 (zeige TRIB2 ELISA Kits) in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
This work aimed to study the porcine tribbles homolog 3 (TRIB3) gene and to evaluate its association with meat quality and carcass traits in pigs.
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.
tribbles homolog 3
, tribbles homolog 3 (Drosophila)
, tribbles homolog 3-like
, neuronal cell death inducible putative kinase
, neuronal cell death-inducible putative kinase
, p65-interacting inhibitor of NF-kappa-B
, p65-interacting inhibitor of NF-kappaB
, induced in fatty liver dystrophy 2
, Neuronal cell death Inducible Putative Kinase
, tribbles 3