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We conducted a genome-wide association meta-analysis and replication study among >105,000 individuals of European ancestry and identified beta-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 x 10(-12)).
obesity appears as the predominant determinant of the abnormalities in FGF21 (zeige FGF21 Antikörper) and FGF19 (zeige FGF19 Antikörper) levels. Opposite changes in beta-Klotho expression in fat and liver indicate potential tissue-specific alterations in the responsiveness to endocrine FGFs in obesity
ATF4 (zeige ATF4 Antikörper) signaling pathway is essential for mediating the effect of ER stress on beta-klotho expression.
Variants in genes involved in feedback regulation of bile acid synthesis (KLB, P=0.06 and FGFR4 (zeige FGFR4 Antikörper), P=0.09) were potentially associated with the irritable bowel syndrome-diarrhea subgroup with elevated serum C4.
In-depth DNA sequencing identified additional genetic coding and noncoding variants in KLB that are associated with fecal bile acids excretion or colonic transit in Irritable bowel syndrome-diarrhea.
betaKlotho suppresses tumor growth in hepatocellular carcinoma by regulating Akt (zeige AKT1 Antikörper)/GSK-3beta/cyclin D1 (zeige CCND1 Antikörper) signaling pathway.
KLB and FGFR1 (zeige FGFR1 Antikörper) form a 1:1 heterocomplex independent of the galectin lattice that transitions to a 1:2 complex upon the addition of FGF21 (zeige FGF21 Antikörper).
KLB-silencing in Huh7 cells decreased cell proliferation and suppressed FGFR4 (zeige FGFR4 Antikörper) downstream signaling.
Differential specificity of endocrine FGF19 (zeige FGF19 Antikörper) and FGF21 (zeige FGF21 Antikörper) to FGFR1 (zeige FGFR1 Antikörper) and FGFR4 (zeige FGFR4 Antikörper) in complex with KLB.
Deletion of the D1 and the D1-D2 linker (the D1/linker region) from FGFR1c led to beta-Klotho-independent receptor activation by FGF21 (zeige FGF21 Antikörper), suggesting that there may be a direct interaction between FGF21 (zeige FGF21 Antikörper) and the D1/linker region-deficient FGFR1c.
liver FGF21 (zeige FGF21 Antikörper)-betaKlotho pathway sufficient and necessary to repress mTOR (zeige FRAP1 Antikörper)/S6K (zeige RPS6KB1 Antikörper) activity
The study supports a pro-adipogenic role for betaKlotho in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (zeige FGFR2 Antikörper)-betaKlotho axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.
Data show that enhancing beta-klotho (KLB) expression in adipose may sensitize to endogenous fibroblast growth factor 21 (FGF21 (zeige FGF21 Antikörper)), thus representing a novel strategy to combat metabolic disease.
Klotho (zeige KL Antikörper) is a novel player in the retina, with a clear connection to photoreceptor cell death as well as with an influence on retinal organization.
Mice lacking the FGF21 (zeige FGF21 Antikörper) co-receptor, beta-Klotho, in the suprachiasmatic nucleus are refractory to the inhibitory effect of FGF21 (zeige FGF21 Antikörper) on female fertility.
The effects of FGF21 (zeige FGF21 Antikörper) are mediated through beta-Klotho expression in the suprachiasmatic nucleus of the hypothalamus and the dorsal vagal complex of the hindbrain.
betaKlotho is required for fibroblast growth factor 21 (zeige FGF21 Antikörper) effects on growth and metabolism.
demonstrate the first manifest evidence revealing that whereas alpha-Kl (zeige KL Antikörper) and beta-Kl are required for FGF23 (zeige FGF23 Antikörper) and FGF15/hFGF19-mediated signaling pathways in vivo, respectively, beta-Kl appears not to be essential for FGF21 (zeige FGF21 Antikörper)-mediated signal transduction in vivo.
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
, klotho beta like
, klotho beta-like protein
, klotho beta, pseudogene 1