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Glucose, insulin, and pyruvate tolerance were impaired in normal mice knocked down for Preb indicating Preb to be a negative regulator of liver gluconeogenic genes.
PREB may contribute to the regulation of ApN gene transcription, in response to cAMP activation in adipocytes.
These data showed that in the adrenal gland, PREB regulates the transcription of the CYP11B1 gene via cAMP.
Both cTAGE5 and SEC12 were exported with TANGO1 in large COPII carriers.
Administration of recombinant adenovirus containing human PREB to db/db, ob/ob, and DIO mice diminished glucose, insulin, and pyruvate tolerance indicating PREB to be a negative regulator of liver gluconeogenic genes.
Wls-SEC12 binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls that fails to communicate with the COPII machinery cannot effectively support Wnt secretion. These data suggest that formation of early Wnt secretory vesicles is carefully regulated to ensure proper export of functional ligands
These results indicate that PREB locates at the hepatitis C virus replication complex by interacting with NS4B.
Sec12, a guanine-nucleotide exchange factor for Sar1 guanosine triphosphatase, is concentrated at endoplasmic reticulum exit sites and that this concentration of Sec12 is specifically required for the secretion of collagen VII but not other proteins.
PREB regulates the cAMP-mediated transcription of the ABCA1 gene in vascular smooth muscle cells
The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells.
This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.
prolactin regulatory element binding protein
, mammalian guanine nucleotide exchange factor mSec12
, prolactin regulatory element-binding protein
, prolactin regulatory binding-element protein