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An exaggerated vasoconstriction response to dexmedetomidine, an alpha-2 adrenergic agonist, has been associated with deletion in the alpha-2B adrenoreceptor gene (ADRA2B deletion).
Data indicate an association of arterial stiffness and platelet alpha2B-Rs gene expression.
full length alpha2B-AR associated with GGA2 (zeige GGA2 Proteine) but not GGA1 (zeige GGA1 Proteine), its third intracellular loop was found to directly interact with both GGA1 (zeige GGA1 Proteine) and GGA2 (zeige GGA2 Proteine). More interestingly, further mapping of interaction domains showed that the GGA1 (zeige GGA1 Proteine) hinge region and the GGA2 (zeige GGA2 Proteine) GAE domain bound to multiple subdomains of the loop.
The ADRA2B DD genotype was associated with Hypertension and was more common in the native population of Mountain Shoria (Siberia).
stress administered immediately before learning selectively enhanced long-term recall in ADRA2B deletion carriers. Stress administered 30min before learning impaired recognition memory in male deletion carriers, while enhancing recognition memory in female deletion carriers.
This study demonstrated that a deletion variant of the ADRA2B gene encoding the alpha2b-adrenoceptor reduces the stress-induced shift from hippocampal cognitive toward dorsal striatal habit memory.
These results identify a beta2-adrenergic-Ca(2+)-actin axis as a new regulator of cell deformability.
ADRA2B SNPs were associated with myocardial infarction susceptibility, blood pressure and plasma lipids.
These findings suggest that deletion variants of ADRA2B may show greater levels of cognitive-affective flexibility compared to non-carriers.
role of GGA3 (zeige GGA3 Proteine) in the cell surface export of alpha2B-adrenergic receptor
alpha2B KO mice exhibit altered locomotor behaviors and compulsive burying behavior, are acutely sensitive to the stereotypy effects of the psychostimulant amphetamine; an identical tendency in alpha2C KO mice administered the alpha2B-receptor-selective antagonist AGN-209419 with amphetamine. Findings suggest a compulsive phenotype for alpha2B KO mice, and a broader role for the alpha2B receptor.
Data indicate that In arrestin 3 (zeige ARRB2 Proteine) deficient mice, where the alpha2B adrenergic receptor has a stronger binding to spinophilin (zeige PPP1R9B Proteine), the hypertensive response is enhanced.
Activation of the adenosine A(2B) receptor protects against vascular injury, while it also enhances plaque stability as indicated by increased collagen content.
Demonstrate that both A(2A)ARs (zeige SLURP1 Proteine) and A(2B)ARs (zeige SLURP1 Proteine) induce coronary flow changes through K(ATP) channels.
alpha(2B)-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog (zeige SHH Proteine)-mediated proliferation of mesenchymal cells and thus prevent respiratory failure
alpha2B adrenoceptor regulated expression is examined in mouse brain development
by blocking G protein receptor kinase 2 association with receptor-Gbetagamma complexes, spinophilin (zeige PPP1R9B Proteine) reduces arrestin (zeige SAG Proteine)- stabilized receptor phosphorylation, receptor endocytosis & acceleration of mitogen-activated protein kinase (zeige MAPK1 Proteine) activity after endocytosis
Loss of Adra2b increases magnitude of hypertension following nitric oxide synthase inhibition.
alpha2B adrenoceptor deficient mice develop a defect in fetal and maternal vessel formation in the placenta.
Overexpression of the alpha(2B)-AR gene leads to increased production of alpha(2B)-AR protein in brain regions known to regulate central sympathetic outflow, thus resulting in sustained BP elevation.
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is norepinephrine > epinephrine.
ADRA2B adrenergic, alpha-2B-, receptor
, G-protein coupled receptor
, adrenergic receptor alpha 2B
, adrenergic, alpha-2B-, receptor
, alpha-2 adrenergic receptor subtype C2
, alpha-2-adrenergic receptor-like 1
, alpha-2B adrenergic receptor
, alpha-2B adrenoceptor
, alpha-2B adrenoreceptor
, Adrenergic alpha2B- receptor class III
, Adrenergic, alpha2B-, receptor class III
, adrenergic receptor, alpha 2b
, subtype alpha2-C2
, alpha adrenergic receptor subtype 2B
, alpha 2b adrenergic receptor
, adrenergic receptor alpha-2B
, alpha-2B adrenergic receptor-like