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C57Bl/6-engrailed-1 (En1+/-) mice do not display the neurodegenerative phenotype, suggesting that susceptibility to En1 heterozygosity is genetically regulated.
En1 is important for ventral nuclei of the lateral lemniscus neuron development and survival.
in absence of En1 and Pitx3, only a limited number of Mesodiencephalic dopaminergic neurons are present in mouse embryo.
Engrailed plays an evolutionarily conserved role in the separate innervation of vertebrate epaxial-hypaxial muscle.
FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform
En1 and Dbx1 microdomains distinguish midbrain dopamine and hypothalamic neurons
En1-null cells also fail to express the transcription factor FoxP1, suggesting that FoxP1 lies downstream of En1.
The homeoprotein Engrailed is not only a survival factor for mesencephalic dopaminergic (mDA) neurons during development, but continues to exert neuroprotective and physiological functions in adult mDA neurons. [Review]
En1+/Otx2 Mutants Exhibit Increased Intra-Individual Fluctuation in Activity, Habituation, Risk-Taking Behavior, Sociability, and Hedonic-Like Behavior.
En1 is involved in two distinct molecular mechanisms that regulate the establishment of neuronal connectivity to limb-musculature.
low-frequency non-coding variant near a novel locus, EN1, with an effect on bone mineral density--which was also associated with a decreased risk of fracture
The findings of this study support a progressive retrograde degeneration of En1(+/-) nigrostriatal neurons, akin to what is suggested to occur in Parkinson disease.
This study identified En1 as a gene essential for MNTB neuron development and Sound localization.
Two crucial mediators of mesodiencephalic dopaminergic neuronal development, En1 and Pitx3, interact in dopaminergic subset specification.
Analysis of an allelic series of conditional mutants showed that En1 is the predominant functional En paralog in maturing 5-HT neurons
En1 and En2 act together in multiple cerebellar cell types to determine overall growth and formation of particular fissures.
En1 has a role in regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary
Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones.
This study characterized En1 and En2 expression around birth and at postnatal day (P) 21 during the period when the cerebellum undergoes a remarkable transformation from a smooth ovoid structure to a highly foliated structure.
The data of this study suggested that in En1+/- mice nigrostriatal degeneration in the substantia nigra is functionally compensated.
Engrailed homeobox 1 was expressed specifically in normal eccrine glands and was expressed in most of the tumour cells of sweat gland neoplasms with eccrine gland differentiation.
our finding suggested that the EN1 rs4144782 might contribute to the susceptibility of knee OA.
EN1 is an activator of intrinsic inflammatory pathways associated with prosurvival in basal-like breast cancer.
The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of neurotransmitter identity.
EN1 is a biologic predictor of poor prognosis in patients with salivary adenoid cystic carcinoma.
Homeobox protein engrailed-1 protein regulates transcription of the utrophin gene.
EN1 might be a negative regulatory factor for UTROPHIN.
The result of this study found a strong association between the EN1 rs1438852 polymorphism and Parkinson's disease.
En-1 exerts its repressive effect by a mechanism negatively controlling the level of beta-catenin.
When beta-catenin is activated in transgenic En1 expressing cells, it induces Dermo1 expression in all cells of the En1 domain and disrupts muscle gene expression.
Genetic variation in human engrailed 1 may influence antipsychotic response in schizophrenia.
Epigenetic suppression along 2q14.2 is common to most colorectal cancers and the presence of a methylated EN1 CpG island in stool DNA might be used as biomarker of neoplastic disease.
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
, engrailed homolog 1
, homeobox protein en-1
, homeobox protein engrailed-1
, homeobox protein en-1a
, homeobox protein engrailed-1a
, engrailed 1