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C57Bl/6-engrailed-1 (En1+/-) mice do not display the neurodegenerative phenotype, suggesting that susceptibility to En1 heterozygosity is genetically regulated.
En1 is important for ventral nuclei of the lateral lemniscus neuron development and survival.
in absence of En1 and Pitx3 (zeige PITX3 Proteine), only a limited number of Mesodiencephalic dopaminergic neurons are present in mouse embryo.
Engrailed plays an evolutionarily conserved role in the separate innervation of vertebrate epaxial-hypaxial muscle.
FGFR (zeige FGFR2 Proteine) Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt (zeige WNT2 Proteine) Signaling in FGF2 (zeige FGF2 Proteine) High Molecular Weight Isoform
En1 and Dbx1 (zeige DBX1 Proteine) microdomains distinguish midbrain dopamine and hypothalamic neurons
En1-null cells also fail to express the transcription factor FoxP1 (zeige FOXP1 Proteine), suggesting that FoxP1 (zeige FOXP1 Proteine) lies downstream of En1.
The homeoprotein Engrailed is not only a survival factor for mesencephalic dopaminergic (mDA) neurons during development, but continues to exert neuroprotective and physiological functions in adult mDA neurons. [Review]
En1+/Otx2 (zeige OTX2 Proteine) Mutants Exhibit Increased Intra-Individual Fluctuation in Activity, Habituation, Risk-Taking Behavior, Sociability, and Hedonic-Like Behavior.
En1 is involved in two distinct molecular mechanisms that regulate the establishment of neuronal connectivity to limb-musculature.
our finding suggested that the EN1 rs4144782 might contribute to the susceptibility of knee OA.
low-frequency non-coding variant near a novel locus, EN1, with an effect on bone mineral density--which was also associated with a decreased risk of fracture
EN1 is an activator of intrinsic inflammatory pathways associated with prosurvival in basal-like breast cancer.
The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of neurotransmitter identity.
EN1 is a biologic predictor of poor prognosis in patients with salivary adenoid cystic carcinoma.
Homeobox protein engrailed-1 protein regulates transcription of the utrophin (zeige UTRN Proteine) gene.
EN1 might be a negative regulatory factor for UTROPHIN (zeige UTRN Proteine).
The result of this study found a strong association between the EN1 rs1438852 polymorphism and Parkinson's disease.
En-1 exerts its repressive effect by a mechanism negatively controlling the level of beta-catenin (zeige CTNNB1 Proteine).
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
, engrailed homolog 1
, homeobox protein en-1
, homeobox protein engrailed-1
, homeobox protein en-1a
, homeobox protein engrailed-1a
, engrailed 1