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The authors show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy.
GINS2 is overexpressed in cervical cancer.GINS2 is a novel indicator of pelvic lymph node metastasis in cervical cancer.
silencing of GINS2 in triple negative breast cancer cells caused dramatic decrease of matrix metalloproteinase-9 (MMP9).
High GINS2 transcript level is associated with endocrine therapy resistance in beast cancer.
On the contrary, after HL60 cells were infected by recombinant adenovirus vector which contained GINS2 gene, we observed that over-expression of GINS2 could promote HL-60 cell proliferation.
GINS2 plays an important role in apoptosis and may function via the p38MAPK signaling pathway.
Data show that using a 200-nt primed circular DNA substrate, the combined action of DNA polymerase epsilon and the Cdc45/Mcm2-7/GINS (CMG complex) leads to the formation of products >10 kb in length.
Data suggest that GINS2 to be associated with the aggressive characteristics of a subgroup of breast cancers in vivo.
Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4\; MIM 610611), Psf1 (GINS1\; MIM 610608), Psf2, and Psf3 (GINS3\; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005
DNA replication complex GINS protein PSF2
, potential GINS DNA replication initiation complex subunit