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Fruit Fly (Drosophila melanogaster) Polyclonal GINS1 Primary Antibody für IHC - ABIN966913
Hoskins, Carlson, Kennedy, Acevedo, Evans-Holm, Frise, Wan, Park, Mendez-Lago, Rossi, Villasante, Dimitri, Karpen, Celniker: Sequence finishing and mapping of Drosophila melanogaster heterochromatin. in Science (New York, N.Y.) 2007
Show all 6 Pubmed References
Human Polyclonal GINS1 Primary Antibody für WB - ABIN653447
Nagahama, Ueno, Miyamoto, Morii, Minami, Mochizuki, Saya, Takakura: PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties. in Cancer research 2010
Show all 3 Pubmed References
Data show the structure of the Cdc45/Mcm2-7/Psf1 GINS (CMG) helicase in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication
The authors show that GINS is a compact tetramer in solution as observed in crystal structures, but also forms a double-tetrameric population, detectable by electron microscopy.
Autosomal recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnatal) growth retardation, chronic neutropenia, and NK cell deficiency.
PSF1 mRNA expression was an independent factor associated with prognosis of colorectal cancer.
These results suggest that PSF1 over-expression is specifically involved in breast cancer cell growth.
Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target.
expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1
the C-terminal domain of Psf1 does not contribute to the stability of the GINS complex but is crucial for chromatin binding and replication activity
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4\; MIM 610611), Psf1, Psf2 (GINS2\; MIM 610609), and Psf3 (GINS3\; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005
DNA replication complex GINS protein PSF1
, DNA replication complex GINS protein psf1
, GINS complex subunit 1
, GINS complex subunit 1 (Psf1 homolog)
, partner of sld five-1
, GINS complex subunit 4 (Sld5 homolog)
, potential GINS DNA replication initiation complex subunit