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this study shows that 53BP1 is required for three-dimensional organization of the immunoglobulin heavy chain locus and provides a plausible explanation for the link with 53BP1 enforcement of deletional immunoglobulin class switch recombination
Genomic instability can be rescued by the deletion of Trp53bp1, which encodes the DNA damage response factor 53BP1, and mice expressing RING-less BRCA1 (zeige BRCA1 Proteine) do not show an increased susceptibility to tumors in the absence of 53BP1.
Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (zeige RAD51 Proteine) and 53BP1 were recruited to these sites. H2AX (zeige H2AFX Proteine) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (zeige H2AFX Proteine) foci formation and DSB repair, whereas H2AX (zeige H2AFX Proteine) was barely stabilized in response to secondary DSBs, in which gammaH2AX (zeige H2AFX Proteine) foci were small and DSBs were not efficiently repaired
Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (zeige SGMS1 Proteine) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.
These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (zeige PRKDC Proteine)-deficient telomeres throughout the cell cycle.
Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (zeige LMNA Proteine) deficiency, which was not observed for heterochromatin-related proteins HP1beta (zeige CBX1 Proteine) and BMI1 (zeige BMI1 Proteine).
Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (zeige E2F1 Proteine) target genes and allows pRb (zeige PGR Proteine) activity to be effectively integrated with the DNA damage response.
study uncovers novel ATM (zeige ATM Proteine)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection
Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP (zeige PAXIP1 Proteine).
Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination
It observed a distinct accumulation of 53BP1 protein to UV-induced DNA lesions: in R273C mutants, 53BP1 appeared transiently at DNA lesions, during 10-30 min after irradiation; the mutation R282W was responsible for accumulation of 53BP1 immediately after UVA-damage; and in L194F mutants, the first appearance of 53BP1 protein at the lesions occurred during 60-70 min.
A reciprocal regulation between 53BP1 and APC (zeige APC Proteine)/C that is required for response to mitotic stress.
The authors identified 53BP1 and USP28 (zeige USP28 Proteine) as essential components acting upstream of p53 (zeige TP53 Proteine), evoking p21 (zeige CDKN1A Proteine)-dependent cell cycle arrest in response not only to centrosome loss, but also to other distinct defects causing prolonged mitosis.
BRCA1 promotes PP4C-dependent 53BP1 dephosphorylation and RIF1 release, directing repair toward homologous recombination.
Co-localization of gammaH2AX (zeige H2AFX Proteine) and 53BP1 indicates promotion of (in)effective nonhomologous end-joining repair mechanisms at sites of DSB. Moreover, gammaH2AX (zeige H2AFX Proteine)/53BP1 foci distribution presumably reveals a non-random spatial organization of the genome in MDS (zeige PAFAH1B1 Proteine) and AML (zeige RUNX1 Proteine).
Results provide evidence that 53BP1 is involved in breast cancer cells resistance for PARP inhibitor; its depletion causes resistance in ATM (zeige ATM Proteine)-deficient tumor cells.
Ubiquitin ligases RNF168 (zeige RNF168 Proteine), RNF169 (zeige RNF169 Proteine), and RAD18 (zeige RAD18 Proteine) specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 chromatin recruitment may be activated by RNF168 (zeige RNF168 Proteine) and blocked by RNF169 (zeige RNF169 Proteine) and RAD18 (zeige RAD18 Proteine).
53BP1 embodies two distinct activities: it can act as a DNA repair factor on the chromatin that flanks double-strand DNA repairs, and it promotes optimal p53 (zeige TP53 Proteine) activity.
Ras-induced senescent cells are hindered in their ability to recruit BRCA1 and 53BP1 to DNA damage sites. Whereas BRCA1 is downregulated at transcripts levels, 53BP1 loss is caused by activation of cathepsin L-mediated degradation of 53BP1 protein. we discovered a marked downregulation of vitamin D receptor (VDR) during OIS, and a role for the vitamin D/VDR axis regulating the levels of these DNA repair
53BP1-USP28 (zeige USP28 Proteine) cooperation is essential for normal p53 (zeige TP53 Proteine)-promoter element interactions and gene transactivation-associated events, yet dispensable for 53BP1-dependent DNA double-strand repair regulation.
May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).
tumor protein p53 binding protein 1
, tumor protein p53 binding protein, 1
, tumor suppressor p53-binding protein 1-like
, tumor protein p53 binding protein 1 (predicted), 5 prime
, tumor protein p53 binding protein 1 (predicted), 3 prime
, murine p53-binding protein
, p53-binding protein 1
, transformation related protein 53 binding-protein 1
, tumor suppressor p53-binding protein 1
, tumor protein 53-binding protein, 1
, tumor protein p53-binding protein, 1
, transformation related protein 53 binding protein 1