anti-Hamster PMS2 Antikörper für Immunoprecipitation

Recommended PMS2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) Antikörper
  • HNPCC4
  • PMS2CL
  • PMSL2
  • AW555130
  • Pmsl2
  • PMS1 homolog 2, mismatch repair system component
  • PMS1 homolog2, mismatch repair system component
  • mismatch repair endonuclease PMS2
  • PMS2
  • Pms2
  • LOC463257
  • LOC107984056
Epitop
AA 58-81
10
8
5
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
Reaktivität
Schimpanse, Hamster, Human, Maus, Ratte (Rattus)
123
41
18
2
2
2
1
1
1
1
1
1
1
1
Wirt
Maus
70
52
1
Klonalität
Monoklonal
Konjugat
Dieser PMS2 Antikörper ist unkonjugiert
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
95
54
53
35
26
19
10
9
2
2
2
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN5550841
$ 619.30
Zzgl. Versandkosten $45.00

General

Antigen PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) Antikörper
Epitop AA 58-81
(10), (8), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Schimpanse, Hamster, Human, Maus, Ratte (Rattus)
(123), (41), (18), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Wirt Maus
(70), (52), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser PMS2 Antikörper ist unkonjugiert
(3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
(95), (54), (53), (35), (26), (19), (10), (9), (2), (2), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-PMS2 Antikörper

Target Details PMS2 Anwendungsinformationen Handhabung Bilder
Spezifität This antibody is directed against PMS2-134 and reacts with full length version of PMS2. The epitope was putatively mapped to amino acids 58-81 of human PMS2. Expect a band approximately 96 kDa in size corresponding to human PMS2 by western blotting in most cell lines and tissues as PMS2 is ubiquitously expressed.
Kreuzreaktivität (Details) Species reactivity (expected):Mouse, Rat, Chimpanzee (100 %)Species reactivity (tested):Human, Hamster
Produktmerkmale Synonyms: PMSL2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2

Concentration: 1.38 mg/mL (by UV absorbance at 280 nm)
Reinigung Protein chromatography
Immunogen Recombinant human PMS2 corresponding to the first 133 amino acid residues of theprotein
Klon 349-29-5-2
Isotyp IgG1
Plasmids, Primers & others

Target Details PMS2

Produktdetails anti-PMS2 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung PMS2 (PMS2 Antibody Abstract)
Hintergrund PMS2 is a highly conserved nuclear protein involved in mismatch repair during DNA replication and has been identified to be composed as a heterodimer of PMS2 and MLH1. PMS is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4), Turcot syndrome (an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas) and supratentorial primitive neuroectodermal tumors with cafe-au-lait spots (SNTCL). The human PMS2 gene encodes an 862 aa, 96 kDa polypeptide.Synonyms: DNA mismatch repair protein PMS2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2, PMSL2
Gen-ID 5395
UniProt P54278
Pathways DNA Reparatur, Production of Molecular Mediator of Immune Response

Anwendungsinformationen

Produktdetails anti-PMS2 Antikörper Target Details PMS2 Handhabung Bilder zurück nach oben
Applikations-hinweise ELISA: 1: 5,000 - 1: 20,000. Western blot: 1: 500 - 1: 2,000. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-PMS2 Antikörper Target Details PMS2 Anwendungsinformationen Bilder zurück nach oben
Konzentration 1.38 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 a buffer and 0.09 % (w/v) Sodium Azide as preservative
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody at 2 °C to 8 °C up to one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Shelf life: one year from despatch.
Haltbarkeit 12 months