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This study assessed the relation of GLS2 downregulation in glioblastoma cells to its methylation and TP53 (zeige TP53 Proteine) status. Aberrant methylation of CpG islands, appear to contribute to silencing of GLS2 in glioblastoma cells by a mechanism bypassing TP53 (zeige TP53 Proteine) mutations.
Non-glutaminolysis function of GLS2 inhibits migration and invasion of hepatocellular carcinoma cells by repressing the epithelial-mesenchymal transition via the Dicer (zeige DICER1 Proteine)-miR (zeige MLXIP Proteine)-34a-Snail (zeige SNAI1 Proteine) axis.
observe that while miR (zeige MLXIP Proteine)-23 is capable of down-regulating the shortened KGA (zeige GLS Proteine) 3'UTR, it has only minor impact on the full-length KGA (zeige GLS Proteine) 3'UTR, demonstrating that additional potent negative regulation of GLS (zeige GLS Proteine) expression exists beyond this single microRNA targeting site
the crystal structure of full-length KGA (zeige GLS Proteine) and present a small-angle X-ray scattering model for full-length GLS2. These structures explain these proteins' compromised ability to assemble into catalytically active supra-tetrameric filaments, as previously shown for GAC (zeige GLS Proteine).
Cox (zeige COX8A Proteine) multivariate regression analysis demonstrated that DUOX1 (zeige DUOX1 Proteine), GLS2, FBP1 (zeige FBP1 Proteine) and age were independent risk factors for the prognosis of HCC (zeige FAM126A Proteine) patients after surgery
As a p53 target, GLS2 mediates p53's function in metastasis suppression through inhibiting Rac1.
IDO (zeige IDO1 Proteine), through GCN2 (zeige EIF2AK4 Proteine) kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (zeige MYC Proteine), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (zeige LDHA Proteine) and GLS2
GABAergic neurons and astrocytes express Gls (zeige GLS Proteine) and Gls2 isoenzymes in nucleus and mitochondria, in addition to glutamatergic neurons
Phosphate-activated glutaminase and GAD65 (zeige GAD2 Proteine)/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls
GLS2 expression is significantly decreased in hepatocellular carcinoma.
Gls2 expression is regulated by the dietary protein/carbohydrate ratio. This effect was not observed in Ppara (zeige PPARA Proteine)-null mice.
Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented.
Phosphate-activated glutaminase (GLS2) is a p53 (zeige TP53 Proteine)-inducible regulator of glutamine (zeige GFPT1 Proteine) metabolism and reactive oxygen species
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene.
, L-glutamine amidohydrolase
, breast cell glutaminase
, glutaminase I
, glutaminase liver isoform, mitochondrial
, phosphate-activated glutaminase
, phosphate-dependent glutaminase
, liver mitochondrial glutaminase