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High ITGA6 expression is associated with colorectal cancer.
Human pluripotent stem cells promote the expression of integrin alpha6beta1, and nuclear localization and inactivation of FAK (zeige PTK2 Proteine) to supports stem cell self-renewal.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R (zeige IGF1R Proteine).
By directly binding to the 3'UTRs of ITGA6 and ITGB1 (zeige ITGB1 Proteine), we found miR (zeige MLXIP Proteine)-30e-5p to suppress mainly the adhesion of ITGA6 in CRC (zeige CALR Proteine) cells to laminin.Taken together, miR (zeige MLXIP Proteine)-30e-5p is a novel effector of P53 (zeige TP53 Proteine)-induced suppression of migration, invasion and metastasis
The SALL4 (zeige SALL4 Proteine) - integrin alpha6 - integrin beta1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells.
FACS analysis of primary human Benign Prostatic Hyperplasia tissues confirms expansion of CD49f basal epithelia in patients with Basal cell hyperplasia.
alpha6(high)/CD71 (zeige TFRC Proteine)(low) cells give rise to a thicker pluristratified epithelium with lower seeding density and display a low Ki67 (zeige MKI67 Proteine) positive cells number, showing that they have reached the balance between proliferation and differentiation.
The A380T Single Nucleotide Polymorphism of the ITGA6 gene was not associated with breast cancer development in the analyzed population of Misiones, Argentina.
Positive Thy1 (zeige THY1 Proteine) and CD49f expression is significantly associated with the progression and poor prognosis of chondrosarcoma.
Ahr (zeige AHR Proteine) ligand aminoflavone targets breast cancer cells with stem cell-like properties, at least in part by abolishing alpha6-integrin expression.
RFX1 (zeige RFX1 Proteine) transcriptionally targets Itga6 in Sertoli cells, thereby, helping maintain the integrity of the basal lamina during testis cord development.
ITGA6 maintains structural integrity of the kidney collecting system.
Integrin alpha 6 Expression on Microglia Surface and Motility on Laminin Is Up-regulated upon Adenosine Diphosphate Stimulation.
interaction of alpha6beta1 in embryonic stem cells (ECCs) with laminin-1 (zeige LAMA1 Proteine) activates alpha6beta1/CD151 (zeige CD151 Proteine) signaling which programs ESCs (zeige NR2E3 Proteine) toward the endothelial cells lineage fate
Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak (zeige ZAK Proteine), Gpr155, and Mtx2 (zeige MTX2 Proteine)) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.
Immunohistological analysis of the tumors showed that Tie2 (zeige TEK Proteine)-dependent a6 gene deletion was associated with reduced tumor vascularization and with reduced infiltration of proangiogenic Tie2 (zeige TEK Proteine)-expressing macrophages
CD29 (zeige ITGB1 Proteine) and CD49f have a critical role of in mediating cancer metastasis.
NLGN1 (zeige NLGN1 Proteine) and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 (zeige NLGN1 Proteine) deletion causes an aberrant VE-cadherin (zeige CDH5 Proteine), laminin and alpha6 integrin distribution in vessels
alpha6 integrin is an essential upstream regulator of the IGF-1R (zeige IGF1R Proteine) survival pathway that regulates the activity level of caspase-3 (zeige CASP3 Proteine) for it to signal differentiation initiation of lens epithelial cells.
formation of CD151 (zeige CD151 Proteine)-integrin complex was likely to be a prerequisite for CD151 (zeige CD151 Proteine)-induced angiogenesis and signaling pathways
Equine herpesvirus type 1 infection significantly decreased the expression of integrin alpha 6 in nasal mucosa epithelial cells.
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
CD49 antigen-like family member F
, integrin alpha-6
, integrin alpha6B
, integrin, alpha 6
, integrin alpha 6
, integrin alpha 6 subunit
, integrin alpha chain, alpha 6
, integrin alpha-6-like