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purified and functionally characterized the critical transcription factor HiNF-P, which is required for E2F-independent activation of the histone H4 multigene family
These results suggest that transcriptional repression of Rb by MIZF could be one of the critical determinants in myogenic differentiation.
HiNF-P interacts directly with p220(NPAT) to coactivate histone genes during S phase.
the transcriptional silencing of the 14-3-3sigma gene is caused by promoter CpG island methylation associated with MBD2, which may play an important role in prostate cancer progression during the invasive and metastatic stages of the disease
These results suggest that RFP is a mediator connecting several MBD proteins and allowing the formation of a more potent transcriptional repressor complex.
HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription.
HiNF-P-dependent stabilization of p220NPAT reinforces signaling through the cyclin E/CDK2/p220NPAT pathway and contributes to coordinate control of histone gene expression.
HiNF-P/P220NPAT regulates expression of nonhistone targets that influence competency for cell cycle progression.
a novel HiNF-P-specific conserved region represents a DNA-binding determinant that plays a role in mediating histone gene expression during the cell cycle and defines HiNF-P as a cell cycle regulatory member of the zinc finger transcription factor family
Results suggest that cyclin-dependent kinase inhibitors selectively control stimulation of the histone H4 gene promoter by the p220(NPAT)/HiNF-P complex.
This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.
MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein
, MBD2-interacting zinc finger 1
, MBD2-interacting zinc finger protein
, histone H4 gene-specific protein HiNF-P
, histone nuclear factor P
, methyl-CpG-binding protein 2-interacting zinc finger protein
, MBD2-interacting zinc finger