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anti-Human FOXC1 Antikörper:
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Human Polyclonal FOXC1 Primary Antibody für ChIP, ELISA - ABIN249940
Dagenais, Hartsough, Erickson, Witte, Butler, Glover: Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. in Gene expression patterns : GEP 2004
Show all 11 Pubmed References
Human Polyclonal FOXC1 Primary Antibody für ICC, IF - ABIN4312329
DeGraff, Grabowska, Case, Yu, Herrick, Hayward, Strand, Cates, Hayward, Gao, Walter, Buttyan, Yi, Kaestner, Matusik: FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype. in Laboratory investigation; a journal of technical methods and pathology 2014
This study demonstrates that FOXC1 induces cancer stem cells (CSCs)-like properties in non-small cell lung cancer (NSCLC) by promoting beta-catenin expression. The findings indicate that FOXC1 is a potential molecular target for anti-CSC-based therapies in NSCLC
Foxc1 promoted cell proliferation by upregulation PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling, which was inflammation-dependent.
Knockdown of FOXC1 markedly suppressed cell migration and invasion in vitro, and resulted in downregulation of phosphorylatedRACalpha serine/threonineprotein kinase, protooncogene cMyc (zeige MYC Antikörper) and Bcell lymphoma 2.
Results provide evidence that FOXC1 is not required for initiation of EMT (zeige ITK Antikörper) events but rather participates in the specification of mesenchymal cell phenotype through regulation of FGF receptor (zeige FGFR2 Antikörper) switching from FGFR2 (zeige FGFR2 Antikörper)-IIIb to FGFR1 (zeige FGFR1 Antikörper)-IIIc in response to TGFb1 (zeige TGFB1 Antikörper)-induced EMT (zeige ITK Antikörper).
In regulating cervical cancers metastasis by targeting FOXC1.
Forkhead box C1 protein (FOXC1) promotes melanoma cell function by regulating macrophage stimulating 1 receptor (MST1R (zeige MST1R Antikörper)) and activating MST1R (zeige MST1R Antikörper)/PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) pathway.
expression of FOXC1 in BRCA1 mutant cell lines correlates with sensitivity to olaparib. Whether this is due to rates of proliferation or another mechanism is yet to be explored, but this, and the specificity of FOXC1 in BRCA1-mutant tumors, suggests a possible role for FOXC1 as a marker for targeted therapy.
novel EGFR (zeige EGFR Antikörper)-NF-kappaB (zeige NFKB1 Antikörper)-FOXC1 signaling axis that is critical for BLBC cell function
Taken together, these data indicate that FOXC1 is a novel hypoxia-induced transcription factor and plays a critical role in tumor microenvironment-promoted lung cancer progression.
Genomic analysis of blood and excised valve tissue showed down-regulation of FOXC1 but also FOXC2 (zeige FOXC2 Antikörper) expression in the diseased aortic valve. This allows us to speculate on the potential role of FOXC1 in aortic valve anomalies.
Lineage tracing experiments in Foxc1 mutant mouse cerebella indicate that aberrant migration of granule cell progenitors destined to form the posterior-most lobule causes this cerebellar malformation phenotype.
Foxc1 regulates both early cardiomyogenesis and the functional properties of embryonic stem cell-derived cardiomyocytes.
FOXC1 and FOXC2 (zeige FOXC2 Antikörper) are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases
These data indicate that Foxc1 expression is regulated by BMP4 (zeige BMP4 Antikörper) and FOXC1 functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds.
Foxc1 regulates sweat duct luminal cell differentiation and mimic apocrine miliaria.
Compound, NC-specific Foxc1; Foxc2 (zeige FOXC2 Antikörper) homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2 (zeige PITX2 Antikörper), and its downstream effector Dkk2 (zeige DKK2 Antikörper), which antagonizes canonical Wnt (zeige WNT2 Antikörper) signaling.
These findings offer the first evidence for a role of the meninges in brain vascular development and provide new insight into potential causes of cerebrovascular defects in patients with FOXC1 mutations.
Foxc1 and Foxc2 (zeige FOXC2 Antikörper) maintain glomerular podocyte integrity by regulating the gene expression.
Foxc1 and Foxc2 (zeige FOXC2 Antikörper) have a role in kidney and axial skeleton development.
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.FOXC1 is necessary to establish a multiple-bulge hair follicle architecture.
Identify mesodermal foxc1a/b as a direct upstream regulator of etsrp (zeige ETV2 Antikörper) in angioblasts. This establishes a new molecular link in the process of mesoderm specification into angioblast.
This study reveals an important role for FOXC1 in the direct regulation of the FGF19 (zeige FGF19 Antikörper)-FGFR4 (zeige FGFR4 Antikörper)-MAPK (zeige MAPK1 Antikörper) pathway to promote both the development and maintenance of anterior segment structures within the eye.
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined\; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.
forkhead box protein C1
, forkhead, drosophila, homolog-like 7
, forkhead-related activator 3
, forkhead-related protein FKHL7
, forkhead-related transcription factor 3
, forkhead/winged helix-like transcription factor 7
, myeloid factor-delta
, forkhead box C1
, forkhead box protein C1-B
, Forkhead box protein C1
, congenital hydrocephalus
, mesoderm/mesenchyme forkhead 1
, transcription factor FKH-1
, winged helix protein CWH-6
, winged-helix transcription factor
, forkhead box C1-B