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Human Sphingomyelin Synthase 1 Protein expressed in Wheat germ - ABIN1319834
Lafont, Milhas, Carpentier, Garcia, Jin, Umehara, Okazaki, Schulze-Osthoff, Levade, Benoist, Ségui: Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. in Cell death and differentiation 2010
SMS (zeige SMS Proteine) regulates the expression and function of drug transporters P-gp (zeige ABCB4 Proteine) and MRP2 (zeige ABCC2 Proteine).
HepG2 cells stably transfected with SMS1 (HepG2-SMS1) exhibit elevated enzyme activity in vitro and increased sphingomyelin content (mainly C22:0- and C24:0-sphingomyelin) but lower hexosylceramide (Hex (zeige HHEX Proteine)-Cer (zeige CBLN1 Proteine)) levels.
Sphingomyelin synthase 1 positively regulates KCNQ1 (zeige KCNQ1 Proteine)/KCNE1 (zeige KCNE1 Proteine) channel density in a protein kinase D (zeige PRKD1 Proteine)-dependent manner.
A study of the expression of the full-length SMS1 protein and the sum of the alternative transcripts encoding this protein in human tissues.
The structural organization of 5'-UTR variants of SGMS1 transcripts, directed by alternative promoters, is substantially different; this can provide regulation of the gene functioning on post-transcriptional level.
We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS (zeige UGCG Proteine)) in the endometrium of endometriotic women.
SGMS activity impacts on amyloid precursor protein (zeige APP Proteine) processing to produce amyloid-beta (Abeta (zeige APP Proteine)) and it could be a contributing factor in Abeta (zeige APP Proteine) pathology associated with Alzheimer's disease.
The amount of SMS1 transcripts varies considerably between different human tissues.
Findings indicate that Sms1 is a downstream target of Bcr-abl (zeige ABL1 Proteine), involved in sustaining cell proliferation of Bcr-abl (zeige ABL1 Proteine)-positive cells.
SMS1 and SMS2 (zeige SGMS2 Proteine) are capable of regulating TGN (zeige TG Proteine)-mediated protein trafficking and secretion
Study has shown that sphingomyelin synthase 1 regulates ceramide levels in N2a cells and plays a potent protective role in this oxidative stress-induced (zeige SQSTM1 Proteine) apoptosis partly through the p38 (zeige CRK Proteine) pathway.
SMS1 has a wider than anticipated role in testis polyunsaturated fatty acid homeostasis and for male fertility
Sphingomyelin synthase 1 regulates Neuro-2a cell proliferation and cell cycle progression through modulation of p27 (zeige CDKN1B Proteine) expression and Akt (zeige AKT1 Proteine) signaling
study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity
that SMS1 is crucial to control oxidative stress in order to maintain white adipose tissue function.
Defects in the stria vascularis with reductions in endocochlear potentials together with hair cell dysfunction may account, at least partially, for hearing impairments in SMS1-/- mice.
The deficiency of membrane sphingomyelin caused the CD4 (zeige CD4 Proteine) T-cell dysfunction through impaired lipid raft function contributing to protection of ConA-induced liver injury, and suggesting that the membrane sphingomyelin is critical for full T-cell activation.
Sms1 deficiency decreases sphingomyelin, but dramatically increases the levels of glycosphingolipids. Atherosclerosis in Sms1(-/-)-->Ldlr (zeige LDLR Proteine)(-/-) mice is significantly decreased.
SMS1 and SMS2 (zeige SGMS2 Proteine) play distinct roles in regulating local sphingomyelin clustering.
SMS1-mediated SM synthesis directs Tf-TfR to undergo clathrin-dependent endocytosis and recycling, promoting the proliferation of lymphoma cells.
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain.
phosphatidylcholine:ceramide cholinephosphotransferase 1
, sphingomyelin synthase 1
, phosphatidylcholine:ceramide cholinephosphotransferase 1-like
, medulla oblongata-derived protein
, protein Mob
, transmembrane protein 23