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anti-Human IRF8 Antikörper:
anti-Mouse (Murine) IRF8 Antikörper:
anti-Rat (Rattus) IRF8 Antikörper:
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Human Polyclonal IRF8 Primary Antibody für ELISA, WB - ABIN1002562
Weisz, Marx, Sharf, Appella, Driggers, Ozato, Levi: Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. in The Journal of biological chemistry 1993
Show all 4 Pubmed References
Human Polyclonal IRF8 Primary Antibody für ELISA, WB - ABIN561405
Conzelmann, Wagner, Hildebrandt, Rodionova, Hess, Zota, Giese, Falk, Ho, Dreger, Hecker, Luft: IFN-? activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production. in Biochemical pharmacology 2010
Cow (Bovine) Polyclonal IRF8 Primary Antibody für WB - ABIN2777225
Ye, Wang, Wang, Wang, Song, Hou, Zhou, Li, Ho: CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes. in Hepatology (Baltimore, Md.) 2009
The vertical and paralleled Pu.1/Spi-b (zeige SPIB Antikörper) regulatory networks control the development of rostral blood island and ventral wall of dorsal aorta-borne macrophages by regulating Irf8.
Study reveals that specification of all macrophages requires irf8 during an early period of zebrafish hematopoiesis but not during the adult-phase. Also, Irf8 seems to have essential roles in host defense as well.
Irf8 is a critical determinant for neutrophil versus macrophage fate choice during zebrafish primitive myelopoiesis.
Study shows that hypermethylation of IRF8 associated with decreased mRNA expression in dendritic cells confers risk to VKH disease.
IRF8 upregulation in tumor cells inhibited the generation of Th17 cells in vitro, and this may be mediated by the downregulation of RORgammat. we found that a high level of IRF8 in the DLBCL tumor microenvironment was a predictor of poor survival in DLBCL patients.
These findings identify IRF8 as a novel tumor suppressor regulating IFN-gamma (zeige IFNG Antikörper)/STAT1 (zeige STAT1 Antikörper) signaling and beta-catenin (zeige CTNNB1 Antikörper) signaling in breast cancer.
Irf8 induction, but not its knockdown, decreased APL (zeige FASL Antikörper) leukemogenic potential through driving monocytic maturation.
Total cellular protein presence of the transcription factor IRF8 does not necessarily correlate with its nuclear presence.
IRF8 is dispensable for induced pluripotent stem cell and embryonic stem cell differentiation into hemogenic endothelium and for endothelial-to-hematopoietic transition.
TP(thymidine phosphorylase (zeige TYMP Antikörper) ) curbed the expression of three proteins-IRF8, RUNX2 (zeige RUNX2 Antikörper), and osterix (zeige SP7 Antikörper). This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) signaling and increased the methyltransferase DNMT3A's expression
It findings provide evidence for an additional mechanism of epigenetic IRF8 silencing during osteoclastogenesis that likely works cooperatively with DNA methylation (zeige HELLS Antikörper), further emphasizing the importance of IRF8 as a negative regulator of osteoclastogenesis.
Data suggest that ubiquitin specific protease 4 (USP4 (zeige USP4 Antikörper)) interacts with interferon regulatory factor 8 (IRF8) and, by its Lys48-specific deubiquitinase/endopeptidase activity, stabilizes IRF8 protein levels in regulatory T-lymphocytes; USP4 (zeige USP4 Antikörper) and IRF8 are also expressed in helper T-lymphocytes.
these data indicate that human NK cells require IRF8 for development and functional maturation and that dysregulation of this function results in severe human disease, thereby emphasizing a critical role for NK cells in human antiviral defense.
Study shows that IRF8 is required for Th9 differentiation in vitro and in vivo. IRF8 functions through a transcription factor complex consisting of IRF8, IRF4 (zeige IRF4 Antikörper), PU.1 and BATF, which binds to DNA and boosts Il9 (zeige IL9 Antikörper) transcription.
Expression of IRF-8 is significantly elevated in the microglia of AD mice. Silencing of IRF-8 abolished Abeta1-40-induced microglia activation.
DNA methylation (zeige HELLS Antikörper) plays a protective role in cisplatin-induced acute kidney injury by regulating specific genes, such as Irf8.
IRF8 does not play an essential intrinsic role in Th17 cell differentiation.
frequencies of antigen-experienced CD4 (zeige CD4 Antikörper)+CD11ahiCD49dhi cells that were CD44hiCD62L- were similar in MLN (zeige MLN Antikörper) of infected Irf8-/- and B6 mice, but the proportions of CD4 (zeige CD4 Antikörper)+GATA3 (zeige GATA3 Antikörper)+ and CD4 (zeige CD4 Antikörper)+IL-4 (zeige IL4 Antikörper)+ T cells were lower in infected Irf8-/- mice
Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.
results show that polymorphonuclear-myeloid-derived suppressor cells arise from a newly defined granulocyte progenitors (GP) stage within the bone marrow and that IRF8 levels (and/or their downstream target genes) in those GPs (zeige NBEAL2 Antikörper) guide their expansion or contraction
IRF8 differentially controls the survival.
IRF8 might play a role in restraining excess lymphocyte proliferation.
IRF8 controls Th1 immune response in Treg cells independent of T-bet.
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.
, interferon regulatory factor 8
, interferon regulatory factor 8-like
, interferon consensus sequence binding protein 1
, interferon consensus sequence-binding protein
, transcription factor ICSBP
, interferon consensus sequence binding protein