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Glycogenin depletion causes high glycogen (zeige GYS1 Proteine) accumulation in striated (zeige NSDHL Proteine) muscles. Glycogenin depletion alters skeletal muscle functionality. Over - accumulation of skeletal muscle glycogen (zeige GYS1 Proteine) affects oxidative metabolism.
Injection of recombinant adeno (zeige ADORA2A Proteine)-associated virus-1 vector expressing glycogen synthase short hairpin ribonucleic acids into mice with type II glycogen (zeige GYS1 Proteine) storage disease leads to significant reduction in impaired glycogen (zeige GYS1 Proteine) accumulation.
we screened the susceptibility loci for Myocardial infarction (MI) using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages.
We present functional evidence for the pathogenicity of a novel GYG1 missense mutation located in the substrate binding domain.
This study found a single homozygous intronic mutation of GYG1 harbored by five patients, who, except for two siblings, appear to be unrelated but all five live in central or south Sardinian villages.
Depletion of glycogenin-1 and impaired interaction with glycogen synthase underlies a new form of glycogen (zeige GYS1 Proteine) storage disease.
The glucosylation of glycogenin-2 (zeige GYG2 Proteine) was enhanced to 2-4 glucose units by the co-presence of enzymatically active glycogenin-1.
results explain the glycogen (zeige GYS1 Proteine) depletion in the patient expressing only Thr83Met glycogenin-1 and why heterozygous carriers without clinical symptoms show a small proportion of unglucosylated glycogenin-1
Results show that glycogenin becomes inactivated with glycogen (zeige GYS1 Proteine) catabolism and that this event coincides with an increase in glycogenin gene expression as exercise and glycogenolysis progress.
during recovery from prolonged exhaustive exercise, glycogenin mRNA and protein content and activity increase in muscle
GN-1 is conserved, possibly as very small, or nascent, granules when glycogen (zeige GYS1 Proteine) concentration is low. This would provide the ability to rapidly restore glycogen (zeige GYS1 Proteine) during early recovery.
the essential role of the lost single hydrogen bond for UDP-glucose activation leading to glycogenin-bound glycogen (zeige GYS1 Proteine) primer synthesis
This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.
, glycogenin glucosyltransferase