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TBCD protein was localized in the middle region and in the tail of the sperm while in the oocyte the localization was cytosolic.
Authors conclude that TBCD is a novel functional contributor to the mammalian cerebral cortex development, and that the pathological mechanism resulting from the mutations we describe is likely to involve compromised interactions with one or more TBCD-interacting effectors that influence the dynamics and behaviour of the neuronal cytoskeleton.
conclude that the TBCD*ARL2 (zeige ARL2 Proteine)*beta-tubulin (zeige TUBB Proteine) complex represents a functional intermediate in the beta-tubulin (zeige TUBB Proteine) folding pathway whose activity is regulated by the cycling of nucleotides on ARL2 (zeige ARL2 Proteine)
Results identified ARL2 (zeige ARL2 Proteine) and TBCD, as important in tubulin (zeige TUBB Proteine) folding and microtubule dynamics. Both ARL2 (zeige ARL2 Proteine) and TBCD also localize to centrosomes. [review]
variants. We identified two candidate homozygous missense variants, R942Q in the tubulin-folding cofactor D (TBCD) gene and H250Q in the bromo-adjacent homology domain and coiled-coil containing 1 (BAHCC1) gene, located on chromosome 17q25.3 with an interval of 1.4 Mbp (zeige MBL2 Proteine).
Intractable epilepsy, intellectual disability and acquired microcephaly, and cortical atrophy and thinned corpus callosum as major MRI (zeige C7ORF49 Proteine) features, caused by biallelic variants in TBCD.
findings establish that defective TBCD function underlies a recognizable encephalopathy and drives accelerated microtubule polymerization and enhanced microtubule stability, underscoring an additional cause of altered microtubule dynamics with impact on neuronal function and survival in the developing brain
Defects of microtubule formation caused by TBCD mutations may underlie the pathomechanism of a neurodegenerative encephalopathy.
Data show that bovine and human TBCD have functionally identical roles in tubulin (zeige TUBB Proteine) heterodimer assembly, and that the inability of human TBCD to disrupt microtubule integrity can be overcome by siRNA-mediated suppression of expression of Arl2 (zeige ARL2 Proteine).
provides first evidence that beta-tubulin cofactor D plays a role in cells independent of its presumed role in folding tubulin (zeige TUBB Proteine) heterodimers
Cofactor D functions as a centrosomal protein and is required for the recruitment of the gamma-tubulin (zeige TUBG1 Proteine) ring complex at centrosomes and organization of the mitotic spindle
Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex\; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
beta-tubulin cofactor D
, tubulin-folding cofactor D
, tubulin-specific chaperone D