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Human Occludin Protein expressed in Wheat germ - ABIN1313322
Grozdanovic, Čavić, Nešić, Andjelković, Akbari, Smit, Gavrović-Jankulović: Kiwifruit cysteine protease actinidin compromises the intestinal barrier by disrupting tight junctions. in Biochimica et biophysica acta 2016
Endothelial cellsTLR4 strongly regulates retinal vessel permeability by reducing expression of occludin and zonula occludens 1 (zeige TJP1 Proteine).
The zinc sensing receptor, ZnR/GPR39 (zeige GPR39 Proteine), triggers intracellular Ca(2 (zeige CA2 Proteine)+) signalling in colonocytes thereby inducing occludin expression. Moreover, ZnR/GPR39 (zeige GPR39 Proteine) is essential for epithelial barrier recovery in the dextran sodium sulfate (DSS (zeige PMP22 Proteine)) ulcerative colitis model.
Occludin expression by epidermal gammadelta T cells upon activation in response to epidermal stress allows them to move, which could be important for augmentation of immune responses via collaboration with other cells.
Intracellular zinc has an essential role in the maintenance of the intestinal epithelial tight junction barrier through regulation of occludin proteolysis and claudin-3 (zeige CLDN3 Proteine) transcription.
miR-429 could down-regulate the expression of Ocln by targeting the Ocln 3'-UTR, which impaired intestinal barrier function in diabetes mellitus mice.
STAT3 activation downregulates the ZO-1 and occludin levels and increases the endothelial permeability through the induction of VEGF production in retinal endothelial cells.
Tricellulin (zeige MARVELD2 Proteine) is a specific redox sensor and sealing element at 3-cell contacts and may compensate as a redox mediator for occludin loss at 2-cell contacts in vivo and in vitro.
These findings provide evidence for occludin playing a role in the invasion of Toxoplasma gondii in small intestinal epithelial cells.
occludin deficiency increases susceptibility to ethanol-induced colonic mucosal barrier dysfunction and liver damage in mice.
PHD3 (zeige EGLN3 Proteine) protects intestinal epithelial barrier function and reveal a hydroxylase-independent function of PHD3 (zeige EGLN3 Proteine) in stabilizing occludin
ZO-1 (zeige TJP1 Proteine) and occludin are expressed in oocytes and preimplantation embryos, and that ZO-1alpha+ is transcribed by zygotic gene activation and translated from early blastocysts with prominent increase of occludin at the blastocyst stage.
ADMA has potent adverse effects on cell proliferation, intracellular ROS (zeige ROS1 Proteine) generation, cell permeability, levels of ICAM-1 (zeige ICAM1 Proteine), and the tight-junction protein occludin
the presence of occludin at the membrane is dependent in part on calcium-sensitive signaling cascades
cyclic strain modulates both the expression and phosphorylation state of occludin and ZO-1 (zeige TJP1 Proteine) in vascular endothelial cells, with putative consequences for endothelial tight junction assembly and barrier integrity
These data demonstrate a novel mechanism of VEGF (zeige VEGFA Proteine)-induced occludin phosphorylation and ubiquitination that contributes to TJ trafficking and subsequent vascular permeability.
decreased interaction between ZO-1 (zeige TJP1 Proteine) and occludin might contribute to the epiphora occurred in the transplanted submandibular glands
integration of claudin-2 (zeige CLDN2 Proteine), occludin and ZO-1 (zeige TJP1 Proteine) is necessary for maintaining the function of the proximal tubular epithelium.
Molecular studies of the OCLN gene (NM_001205254) identified six distinct candidate mutations in polymicrogyria.
Glutamine increased claudin-1 expression in the colonic mucosa of patients with irritable bowel syndrome. In contrast, occludin expression was not significantly modified by glutamine.
Viral infectivity was significantly reduced by miR (zeige MLXIP Proteine)-200c but enhanced by miR (zeige MLXIP Proteine)-122.
The mechanism of transition from nondifferentiated to differentiated states in HepaRG cells was studed by proteomics. Two key factors (MMP-14 (zeige MMP14 Proteine) and OCLN) were validated by qRT-PCR and Western blot.
Data suggest that long noncoding RNA PlncRNA1 and microRNA miR (zeige MLXIP Proteine)-34c bound together to regulate the expressions of MAZ (zeige MAZ Proteine), ZO-1 (zeige TJP1 Proteine) and occludin.
Study provides evidence that occludin contributes to the regulation of size-reductive proliferation and epithelial cell maturation in a phosphorylation-dependent manner.
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
, tight-junction protein
, thiopurine methyltransferase
, tight junction protein occludin