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PAR3 is essential in thrombin (zeige F2 ELISA Kits) stimulated insulin (zeige INS ELISA Kits) secretion.
TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS (zeige NOS3 ELISA Kits)-Thr (zeige TRH ELISA Kits)-495 with minimal phosphorylation of eNOS (zeige NOS3 ELISA Kits)-Ser (zeige SIGLEC1 ELISA Kits)-1177 with no change in nitric oxide production.
These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR (zeige JTB ELISA Kits) activation, such as the activation of vascular-protective Tie2 (zeige TEK ELISA Kits) by noncanonical PAR3 activation.
In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin (zeige CDH1 ELISA Kits), leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav.
Data indicate that knockdowns of all three PARs (zeige EPRS ELISA Kits) PAR-1 (zeige MARK2 ELISA Kits), PAR-2 (zeige F2RL1 ELISA Kits), and PAR-3 exhibited changes in the expression of CDC42 (zeige CDC42 ELISA Kits), which correlated with the changes in their invasion.
Elevated expression of PAR-3, b (zeige MARK2 ELISA Kits)ut not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients.
A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C (zeige PROC ELISA Kits) cytoprotective effects.
PAR-3 receptors interact with thrombin (zeige F2 ELISA Kits) and increase heme oxygenase-1 (zeige HMOX1 ELISA Kits) expression in synovial fibroblasts.
Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR (zeige ELAVL1 ELISA Kits), whereas transcriptional control involves nuclear factor of activated T cells (NFAT (zeige NFATC1 ELISA Kits)).
FXa (zeige F10 ELISA Kits) bound in a punctate manner to thrombi under shear, while thrombin (zeige F2 ELISA Kits) and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi
Data show that activated protein C (zeige PROC ELISA Kits) signals via protease activated receptors PAR2 (zeige F2RL1 ELISA Kits)/PAR3 to expand Treg cells, mitigating the disease in mice.
found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2 (zeige IQGAP2 ELISA Kits)) and F2rl2
Simultaneous depletion of PAR-1 (zeige MARK2 ELISA Kits) and PAR-3 almost completely inhibited epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.
these data point to a novel kallikrein 6 (zeige KLK1 ELISA Kits) -signaling axis in neurons that is mediated by PAR1 (zeige F2R ELISA Kits) and PAR2 (zeige F2RL1 ELISA Kits) and is positioned to contribute to neurodegeneration
Par3(-/-) mice were protected against ferric chloride-induced thrombosis of mesenteric arterioles and against thromboplastin (zeige F3 ELISA Kits)-induced pulmonary embolism (protease-activated receptor-3 (PAR3)
PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1 (zeige F2R ELISA Kits)-type thrombin (zeige F2 ELISA Kits) receptors
Crystal structures reveal the molecular basis of the cofactor function of cleaved PAR3, bound to exosite I, on recognition of PAR4 (zeige F2RL3 ELISA Kits) by the active site of thrombin (zeige F2 ELISA Kits).
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.
Coagulation factor II receptor-like 2 (protease-actovated receptor 3)
, protease-activated receptor 3
, proteinase-activated receptor 3
, proteinase-activated receptor-3
, thrombin receptor-like 2
, Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)
, coagulation factor II receptor-like 2
, coagulation factor II (thrombin) receptor-like 2 L homeolog