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We revealed that DAL-1 was downregulated while HSPA5 (zeige HSPA5 Proteine) was upregulated in NSCLC and found the protein of DAL-1 and HSPA5 (zeige HSPA5 Proteine) co-localized in the cytoplasm and nucleus. We demonstrated that DAL-1 can suppress the expression of HSPA5 (zeige HSPA5 Proteine) on mRNA and protein levels, and decrease EMT (zeige ITK Proteine), migration, invasion and proliferation abilities by down-regulating HSPA5 (zeige HSPA5 Proteine)
4.1B gene deletion was sufficient to transform SV40T antigen-immortalized mouse embryonic fibroblasts (iMEFs), as reflected by the ability of 4.1B(-/-) iMEFs to growth in the environments that were growth restrictive for 4.1B(+/+) iMEFs and to form tumors in nude mice, whereas 4.1B(+/+) iMEFs were unable to form tumors in vivo.
aberrant expression of DAL-1 by hypermethylation in the promoter region results in tumor suppressor gene behavior that plays important roles in the malignancy of gastric cancers
findings reveal that EPB41L3 suppresses tumour cell invasion and inhibits MMP2 (zeige MMP2 Proteine) and MMP9 (zeige MMP9 Proteine) expression in esophageal squamous cell carcinoma cells
Downregulation of DAL-1/4.1B expression effectively suppresses DAL-1/4.1B protein expression in lung cancer cells.
a central role of CADM1 (zeige CADM1 Proteine) in stabilizing the complex with 4.1B and MPP3 (zeige MPP3 Proteine)
We conclude that EPB41L3, RASSF2 (zeige RASSF2 Proteine) and TSP-1 (zeige THBS1 Proteine) genes are involved in the pathogenesis of diffuse gliomas
Our study demonstrates for the first time that platelet-secreted miR (zeige MLXIP Proteine)-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3.
The results suggest that tumor suppressor DAL-1 could also attenuate epithelial-to mesenchymal transition and be important for tumor metastasis in the early transformation process in lung cancer.
Studies indicate that tumor suppressor protein (zeige TP53 Proteine) 4.1B/DAL-1 plays a crucial regulatory role in cell growth and differentiation.
This paper herein showed the immunolocalization and interaction proteins of MPP6 (zeige MPP6 Proteine) in the mouse small intestine, and also that 4.1B in epithelial cells was not essential for the sorting of MPP6 (zeige MPP6 Proteine).
findings document novel, isoform-selective roles for 130-kDa 4.1B in adhesion, spreading, and migration of MEF cells by affecting actin organization
The results of this study demonstrated that 4.1B is a key cytoskeletal scaffold for axonal adhesion molecules expressed in the juxtaparanodal and internodal domains that unexpectedly regulates myelin sheath thickness.
in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber.
Protein 4.1B plays a key role in ensuring the proper molecular compartmentalization of hemi-node-type region of axons of motor neurons.
4.1B plays a pivotal role in interactions between the paranodal AGSJs and axonal cytoskeleton.
4.1B was specifically and constantly expressed in the stereocilia tips during postnatal development.
Protein 4.1B is localized in islets of Langerhans and may have a role in phenotypic transition from pancreatic adenoma to carcinoma.
protein 4.1B in mouse small intestine & DAL-1 in human colon showed similar distributions in normal intestinal epithelial cells; expression reduced in intestinal carcinoma; may function in preventing malignant transformation of intestinal epithelial cells
4.1B regulates mammary epithelial cell proliferation during pregnancy and suggest that its loss may influence mammary carcinoma pathogenesis
Critical growth regulator in the pathogenesis of meningiomas.
band 4.1-like protein 3
, differentially expressed in adenocarcinoma of the lung protein 1
, erythrocyte protein band 4.1-like 3
, erythrocyte membrane protein band 4.1-like 3 L homeolog
, erythrocyte membrane protein band 4.1-like 3
, erythrocyte membrane protein band 4.1-like 3b