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GAS2 is a critical and novel regulator of tissue remodeling in the ovary during oocyte cyst breakdown and folliculogenesis
these findings suggest that downregulated miR3425p is involved in regulating cell proliferation and cell cycles in Zmpste24 (zeige Zmpste24 Proteine)/ MEFs by suppressing GAS2 in vitro.
Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin (zeige CTNNB1 Proteine)
Taken together, our results demonstrated the deregulation of GAS2 in both AML (zeige RUNX1 Proteine) and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells.
Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 (zeige TP53 Proteine) signaling.
GAS2 is up-regulated in chronic myeloid leukemia (zeige BCL11A Proteine) cells.
Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP (zeige IRF8 Proteine) influences beta-catenin (zeige CTNNB1 Proteine) activity in myeloid leukemia (zeige BCL11A Proteine).
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified.
growth arrest-specific protein 2
, growth arrest-specific 2