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anti-Human GCKR Antikörper:
anti-Rat (Rattus) GCKR Antikörper:
anti-Mouse (Murine) GCKR Antikörper:
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Mouse (Murine) Polyclonal GCKR Primary Antibody für ELISA, WB - ABIN451749
Kathiresan, Melander, Guiducci, Surti, Burtt, Rieder, Cooper, Roos, Voight, Havulinna, Wahlstrand, Hedner, Corella, Tai, Ordovas, Berglund, Vartiainen, Jousilahti, Hedblad, Taskinen, Newton-Cheh et al.: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. ... in Nature genetics 2008
Show all 2 Pubmed References
GCKR rs780094-C is associated with increased risk of gestational diabetes mellitus.[meta-analysis]
Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL (zeige RNASEL Antikörper)), leukocyte immunoglobulin-like receptor 3 (zeige LILRB3 Antikörper) (LILRA3 (zeige LILRA3 Antikörper)), and dynein axonemal heavy chain 10 (DNAH10 (zeige DNAH10 Antikörper)) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc.
Three loci showed robust, replicating association with circulating FXI (zeige F11 Antikörper) levels: KNG1 (zeige KNG1 Antikörper) (rs710446, P-value = 2.07 x 10-302), F11 (zeige F11 Antikörper) (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI (zeige F11 Antikörper) regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin (zeige F3 Antikörper) time
GCKR association with adiposity and the risk of the nonalcoholic fatty liver disease
The existence of a liver-specific FOXA2 (zeige FOXA2 Antikörper)-regulated transcriptional enhancer at an intronic T2D locus represented by rs780094, rs780095, and rs780096 SNPs that increases GCKR expression is demonstrated.
GCKR Leu446 may influence FGF21 (zeige FGF21 Antikörper) expression via its ability to increase glucokinase (GCK (zeige GCK Antikörper)) activity. This can lead to enhanced FGF21 (zeige FGF21 Antikörper) expression via elevated fatty acid synthesis, consequent to the inhibition of carnitine/palmitoyl-transferase by malonyl-CoA, and via increased glucose-6-phosphate-mediated activation of the carbohydrate response element binding protein (zeige MLXIPL Antikörper), known to regulate FGF21 (zeige FGF21 Antikörper) gene expression.
Data suggest that hepatic glucokinase (zeige GCK Antikörper) activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2 (zeige PFKFB3 Antikörper)/FBP2 (zeige KHSRP Antikörper)); changes in glucokinase (zeige GCK Antikörper) expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]
The rs780094 [1.34 (1.21-1.49); p = 8.57 x 10(-8) ] on chr 2 at the glucokinase regulatory protein (GCKR) locus was similarly significantly associated, while the rs10911205 [1.29 (1.16-1.44); p = 3.52 x 10(-6) ] on chr1 at the laminin subunit gamma-1 (LAMC1 (zeige LAMC1 Antikörper)) locus showed suggestive association with disease.
Among Mexicans, the PNPLA3 (zeige PNPLA3 Antikörper) (rs738409), LYPLAL1 (zeige LYPLAL1 Antikörper) (rs12137855), PPP1R3B (zeige PPP1R3B Antikörper) (rs4240624), and GCKR (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults.
The present study explored the association between a common variant of the glucokinase regulator (GCKR) gene and metabolic syndrome and its related traits in Taiwanese adolescents
This study showed that Sirt2 (zeige SIRT2 Antikörper)-dependent GKRP deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes.
Given that acetylated GKRP may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP acetylation in the liver could reveal novel targets within the GK-GKRP pathway, for treating T2DM and other metabolic pathologies.
Glucokinase regulatory protein binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
glucokinase regulatory protein
, glucokinase regulator
, LOW QUALITY PROTEIN: glucokinase regulatory protein
, glucokinase (hexokinase 4) regulator