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Human CXCR1 Protein expressed in Wheat germ - ABIN1330036
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
Human CXCR1 Protein expressed in Wheat germ - ABIN1350834
Bergin, Reeves, Meleady, Henry, McElvaney, Carroll, Condron, Chotirmall, Clynes, ONeill, McElvaney: ?-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. in The Journal of clinical investigation 2010
The presence of neither the first transmembrane helix of the receptor nor the lipid bilayer significantly affected the interactions of IL-8 (zeige IL8 Proteine) with Binding Site-I of CXCR1.
Depletion of receptor accessory proteins REEP5 (zeige REEP5 Proteine) and REEP6 (zeige REEP6 Proteine) causes a decrease in CXC Chemokine Receptor 1 (CXCR1) signaling.
increased production of IL-8 (zeige IL8 Proteine) associated with neutrophils infiltration into the liver and decreased CXCR1/2 expression on peripheral neutrophils. CXCR1 and CXCR2 (zeige CXCR2 Proteine) expression levels could be served as early markers to predict the severity of acute-on-chronic liver failure.
Chemokine receptor CXCR1 (zeige CX3CR1 Proteine) could be used as an indicator to predict benign or malignant breast disease, and it can even predict the malignancy degree of breast cancer, as well as its invasive ability and prognosis.
In this review, we summarize the biological functions and clinical significance of the CXCL8 (zeige IL8 Proteine)-CXCR1/2 signaling pathway in cancer. Targeting CXCL8 (zeige IL8 Proteine) or CXCR1/2 may be an attractive therapeutic strategy for tumors.
Interaction of Monomeric Interleukin-8 (zeige IL8 Proteine) with CXCR1
first study to investigate the concentrations of CXCR-1 and CXCR-2 (zeige CXCR2 Proteine) with the levels of IL-8 (zeige IL8 Proteine) in colostrum and mature human milk of term and preterm newborns
High expression of CXCR1 identified a subgroup of gastric cancer patients who appeared to benefit from 5-FU based adjuvant chemotherapy .
CXCR1-NFkappaB pathway role in human hepatocyte proliferation
The analysis of IL-8 (interleukin-8 (zeige IL8 Proteine)), CXCR1 (IL-8RA - IL-8 receptor alpha) and CXCR2 (IL-8RB (zeige CXCR2 Proteine) - IL-8 receptor beta) expression showed that these molecules are present not only in many different types of inflammatory and endothelial cells, but also in several tumor basaloid, transitional and even few ghost cells.
these studies define CXCR1 as a novel, noncanonical chemokine receptor that regulates pulmonary anti-Pseudomonas host defense with broad implications for cystic fibrosis (zeige S100A8 Proteine), chronic obstructive pulmonary disease and other infectious lung diseases
CXCR1 and CXCR2 (zeige CXCR2 Proteine) regulate hepatocyte exosome release. The mechanism utilized by CXCR1 remains elusive, but CXCR2 (zeige CXCR2 Proteine) appears to modulate Nsm activity and resultant production of ceramide to control exosome release. CXCR1 is required for packaging of enzymes into exosomes that mediate their hepatocyte proliferative effect.
These data demonstrate a biological function for mouse Cxcr1 in vivo and indicate that CXCR1-dependent neutrophil effector function is a critical innate protective mechanism of fungal clearance and host survival in systemic candidiasis.
in view of recently-published experimental data obtained in NOD mice, we argue for possible Cxcr1 involvement in type 1 diabetes pathogenesi
CXCR1 expression is induced in staphylococcus aureus-infected macrophages but not in control macrophages.
Pharmacologic blockade of CXCR1/2 as well as genetic deletion of NAP-2 (zeige PPBP Proteine) markedly reduced leukocyte shape change and intrathrombus migration.
Blockade of the CXCL1 (zeige CXCL1 Proteine)-CXCR1/2 axis in mice improved intrahepatic islet engraftment. The CXCR1/2-mediated pathway is a regulator of islet damage.
Upon activation by CXCL8 (zeige IL8 Proteine), CXCR1 predominantly couples to G protein-coupled receptor (zeige GPR34 Proteine) kinase (GRK)2 (zeige ADRBK1 Proteine) to modulate leukocyte functions.
Xiaotan Sanjie Decoction XTSJD can decrease the protein expressions of IL-8 (zeige IL8 Proteine) and its receptors CXCR1/CXCR2 (zeige CXCR2 Proteine) in tumor xenografts and gastric tissue adjacent to the tumor.
data suggest that CXCR1 does not mediate the proliferative effects of ELR+ CXC chemokines during liver regeneration after partial hepatectomy
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
C-X-C chemokine receptor type 1
, IL-8 receptor type 1
, IL-8R A
, high affinity interleukin-8 receptor A
, interleukin 8 receptor, alpha
, interleukin-8 receptor type 1
, interleukin-8 receptor type A
, CXC chemokine receptor 1
, chemokine (C-X-C motif) receptor 2
, interleukin 8 receptor, beta
, interleukin 8 receptor alpha
, IL-8 receptor
, C-X-C motif chemokine receptor 1 S homeolog
, CXCR2 like protein
, chemokine (C-X-C motif) receptor 1 S homeolog